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Les nitrates en question :

AUDACE interroge le Docteur Christian Buson

[pdf - 111KB]

 

 

 

Colloque Nitrate - Nitrite - Oxyde Nitrique
Nouvelles perspectives pour la santé

sous le patronage de l'Académie Nationale de Médecine

ADICARE Paris 
31 mars 2011
 

Health Symposium Nitrate, Nitrite, Nitric Oxide
New perspective for Health

Under the patronage of France's Medecine Academy

ADICARE Paris 
31  March 2011

 

 

 

 

   « Les deux seuils ­– 5 mg par kilo de poids corporel et 50 mg par litre d’eau de boisson – semblent animé d’une  vie sociale propre.  Les données récentes sur l’innocuité  du nitrate chez l’homme et l’animal d’expérience n’y changent rien.

Pourquoi ?  Les experts  constituant les comités sont à l’évidence parfaitement informés. Et ils ne conseillent pas de supprimer la dose journalière admissible et le seuil de potabilité de 50 mg qui en  découle, parce  qu’ils ne peuvent le faire. Imaginons que,  demain, ils annoncent  que <l’eau est potable quelle  que soit la concentration des nitrates qu’elle  contient> et encore qu’ < une feuille de laitue de 25g contient autant de nitrate qu’un litre d’eau prétendument dangereuse>.

 

    Les réactions des mouvements écologistes, en France mais surtout en Europe du Nord,      seraient d’une violence politique décisive. Les engrais, dont le principal principe actif est justement  les nitrates, sont leur cheval de bataille juste après le danger nucléaire. Et  la population y est grandement sensibilisée.

 

     Et il y aurait aussi un problème de cohérence : comment annoncer qu’il y a  eu  il y a trente-cinq ans erreur, parfaitement  compréhensible au demeurant compte tenu des connaissances à l’époque, que cette erreur fut répercutée en chaîne par des comités, par des instances européennes, par les instances nationales, par les tribunaux, par les médias.

 

     Il y aurait aussi un problème juridique insoluble.  Comment annuler les directives, les décrets, les circulaires tant européens que français ?  Et qu’en serait-il des jugements ?  Faudrait -il faire  rembourser les subventions, les indemnités ?

 

     Les scientifiques  font partie de la société, et en tant qu’experts des institutions. Leur dilemme est simple ; soit par amour de la vérité scientifique, répandre une information scandaleuse car à contre-courant des  convictions de beaucoup, soit  confirmer discrètement une fiction tout à fait inoffensive, car somme toute il n’est pas nécessaire pour la santé publique que l’on boive de l’eau nitratée.

 

      Donc il faut persévérer dans l’être et continuer à faire comme si l’eau contenant plus de 50 mg par litre était à peine potable, et celle à  plus de 100 mg par litre pas potable du tout.  Même si le contraire est scientifiquement démontré.

 

     Mais, puisque tout est ainsi pour le mieux dans le meilleur des mondes possibles, pourquoi en parler ?  Car le dossier des nitrates est exemplaire de ce que la prétention de la science à dire le vrai universel est de plus  en plus contestée, entre autres à cause de l’évidente symbiose du  scientifique et du politique et de ce qu’un fait social puisse perdurer au-delà de ses causes » [Mariam APFELBAUM]


 


06 04 2005

Directive nitrate :   

EU allows for derogation by the Netherlands from Annex III.2 of the Nitrates Directive

[DOC .pdf] Derogation memorandum - Derogation from the Nitrates Directive in ...

 

L'Europe accorde une dérogation à la règle communautaire aux Pays-Bas et sauve 50 % de l'élevage intensif

Les Pays Bas avait introduit un recours contre la directive nitrate en démontrant que celle-ci  ne prenait pas suffisamment en compte les conditions pédoclimatiques  locales.

L'information complète est disponible sur le site Agris©   ("Le Futur Aujourd'hui" SPRL)
Tel +32 (0)19 63 28 83    -    info@agris.be

 

Réaction :

« Sur le fond, il ne faudrait pas longtemps aujourd’hui pour que soit tranchées officiellement et sur la base d’arguments scientifiques irréfutables différentes questions : 

-          innocuité totale des nitrates, sinon interdiction de la production et de la vente libre des légumes, ce qui entraînerait une grave erreur de politique sanitaire, (la promotion du dernier livre des Dr L’hirondel peut être renforcée !)

-          impact nul des nitrates sur l’eutrophisation des eaux douces et marines aux concentrations courantes observées dans les écosystèmes européens (« masses d’eau » de la loi cadre ?)

Par conséquent nous ne sommes pas dans l’inexactitude ou la nuance, mais bien dans l’erreur profonde, grave et irrémédiable. Ce qui est proprement sidérant, c’est  l’attitude constante de crispation des autorités françaises et européennes et leur refus sous différents prétextes, tous plus futiles les uns que les autres, d’aborder le réexamen sur le fond de cette question. Que cette erreur soit coûteuse, inutilement contraignante et qu’elle participe à une formidable diversion collective, ne semble guère gêner nos technocrates, qui font plus dans la pseudo analyse psychologique que dans la juste appréciation des politiques publiques.

Même la notion d' « intérêt pour la sensibilisation du monde agricole aux problèmes environnementaux » qui reste le dernier argument parfois avancé, pour maintenir le statut quo, n’est pas soutenable : comment « sensibiliser  juste » sur un faux problème avéré, qui génère en outre des contraintes et des dépenses publiques et privées, aussi lourdes qu’injustifiées. Cette fumeuse « sensibilisation » risque fort de se retourner contre ses propagandistes, lorsque la vérité sera comprise du plus grand nombre ! Et la synthèse sur la chimie de l’environnement ne devrait pas tarder à être comprise... »

 

Propos recueillis de Christian BUSON de l'Institut de l'Environnement

http://www.institut-environnement.fr/     pig-cow_audace.gif (195817 bytes)

page nitrate

 


 

09 01 2007

 

« L'Allemagne obtient après les Pays-Bas une dérogation à la Directive Nitrate  »

 

« Le parallèle est d'autant plus frappant que les Pays-Bas avaient obtenu cette dérogation (si ma mémoire ne fait pas défaut), lors de leur présidence de l'UE.

 

La dérogation permet à l'Allemagne d'autoriser l'application de 230 kg de nitrates par ha et par an au lieu des 170 kg prévu par la directive, ceci dans les prairies intensives d'exploitations spécifiques. L'application de nitrate sur les terres des exploitations ne pourra cependant dépassés les 170 kg d'azote par ha et par an (Décision 2006/1013/CE) La dérogation a été accordée jusqu'en 2009.

 

On estime que cette dérogation touche 13.500 exploitations couvrant 500.000 ha ce qui correspond à 2,4 % des exploitations, 2,9 % de la surface utilisée et 0,7 % des lisiers produits. Celles-ci se rencontrent principalement en Haute Bavière, Baden Wurttemberg (Tubinga), Basse Saxe et Schleswig-Holstein. Pour obtenir cette dérogation l'administration allemande a argumenté que le nombre de bovins avait diminué de -25 %. L'apport de fumier ou lisier à l'ha a diminué de 11 % entre 1991-1993 et 2002-2004. L'application de nitratre a diminué pendant la même période de 120 à 101 kg/ha. La concentration en nitrate dans les eaux superficielles a diminué de 83 % sur les sites de prélèvements.

 

Les néerlandais eux avaient argumentés une meilleure absorption des nitrates du au climat doux.  »  

 

(article d’Agris 2007-9-1, Thyrion Dominique [info@agris.be])

 

Agris© is a TradeMark of Synergie "Le Futur Aujourd'hui" SPRL
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ATTENTION, ILS SONT BONS POUR LA SANTE

     SCIENCE & VIE,  octobre 2012   [PDF - 987 KB]

 


BIBLIOGRAPHY

 

Abrahams, M., Sjöberg, F., Oscarsson, A. et Sundqvist, T. (1999) The effect of human burn injury on urinary nitrate excretion. Burns 25, 29-33.

 

Acheson, E.D. (1985) Nitrate in Drinking Water. HMSO London CMO(85), 14.

 

Addiscott, T.M. (1996) Fertilizers and nitrate leaching. Issues in Environmental Science and Technology 5, 1-26.

 

Addiscott, T.M. (2000) Making a meal of it. New Scientist 165, 5 February 2000, 48-49.

 

Addiscott, T.M. et Benjamin, N. (2000) Are you taking your nitrate? Food Science and Technology Today 14, 59-61.

 

Addiscott, T.M., Whitmore, A.P. et Powlson, D.S. (1991) Farming, Fertilizers and the Nitrate Problem. CAB International, Wallingford, UK, 170 pp.

 

Adelon et coll. (1824) Dictionnaire abrégé des Sciences Médicales. Panckoucke, Paris.

 

Agunod, M., Yamaguchi, N., Lopez, R., Luhby, A.L. et Glass, G.B.J. (1969) Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in new-borns and infants. American Journal of Digestive Diseases 14, 400-414.

 

Ahren, C., Jungersten, L. et Sandberg, T. (1999) Plasma nitrate as an index of nitric oxide formation in patients with acute infectious diseases. Scandinavian Journal of Infectious Diseases 31, 405-407.

 

Akerblom, H.K. et Knip, M. (1998) Putative environmental factors in type I diabetes. Diabetes/Metabolism Reviews 14, 31-67.

 

Al-Dabbagh, S., Forman, D., Bryson, D., Stratton, I. et Doll, R. (1986) Mortality of nitrate fertiliser workers. British Journal of Industrial Medicine 43, 507-515.

 

Anggard, E. (1994) Nitric oxide: mediator, murderer, and medicine. Lancet 343, 1199-1206.

 

Anon. (1996) UK scores partial success over EC nitrate limits in vegetables. ENDS Report 253, 44.

 

Apfelbaum, M. (1998) Nitrates dans l’eau de boisson. In: Apfelbaum, M. (ed.) Risques et peurs alimentaires. Editions Odile Jacob, Paris, pp 15-22.

 

Apfelbaum, M. (2001) Nitrates: une norme aux pieds d'argile. La Recherche (Paris) 339, 31-34.

 

APHA (1949-1950) Committee on water supply: nitrate in potable waters and methemoglobinemia. American Public Health Association. Yearbook 40, 5, 110-115.

 

Arbuckle, T.E., Sherman, G.J., Corey, P.N., Walters, D., et Lo, B. (1988) Water nitrates and CNS birth defects: a population-based case-control study. Archives of Environmental Health 43, 162-167.

 

Armijo, R., Gonzalez, A., Orellana, M., Coulson, A.H., Sayre, J.W. et Detels, R. (1981) Epidemiology of gastric cancer in Chile: II - Nitrate exposures and stomach cancer frequency. International Journal of Epidemiology 10, 57-62.

 

Aschengrau, A., Zierler, S. et Cohen, A. (1989) Quality of community drinking water and the occurrence of spontaneous abortion. Archives of Environmental Health 44, 283-290.

 

Astier-Dumas, M. (1976) Cuisson à l’eau et teneur en nitrates de quelques végétaux. Devenir concomitant d’autres éléments nutritifs. Annales de la Nutrition et de l’Alimentation 30, 683-688.

 

Aussannaire, M., Joly, C. et Pohlmann, A. (1968) Méthémoglobinémie acquise du nourrisson par eau de canalisation urbaine. Presse médicale 36, 1723-1726.

 

Avery, A.A. (1999) Infantile methemoglobinemia: reexamining the role of drinking water nitrates. Environmental Health Perspectives 107, 583-586.

 

Avery, A.A. (2001) Cause of methemoglobinemia: illness versus nitrate exposure. Environmental Health Perspectives 109(1), A12-A13.

 

Avery, G.B., Randolph, J.G. et Weaver, T. (1966) Gastric acidity in the first day of life. Pediatrics 37, 1005-1007.

 

Avontuur, J.A.M., Stam, T.C., Jongen-Lavrencic, M., van Amsterdam, J.G.C., Eggermont, A.M.M. et Bruining, H.A. (1998) Effect of L-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF and nitrite/nitrate in human septic shock. Intensive Care Medicine 24, 673-679.

 

Ayebo, A., Kross, B.C., Vlad, M. et Sinca, A. (1997) Infant methemoglobinemia in the Transylvania Region of Romania. International Journal of Occupational and Environmental Health 3, 20-29.

 

Barak, N., Zemel, R., Ben-Ari, Z., Braun, M. et Tur-Kaspa, R. (1999) Nitric oxide metabolites in decompensated liver cirrhosis. Digestive Diseases and Sciences 44, 1338-1341.

 

Barrett, J.H., Parslow, R.C., McKinney, P.A., Law, G.R. et Forman, D. (1998) Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England. Cancer Causes and Control 9, 153-159.

 

Barroin, G. (1992) Mécanismes biologiques de l’eutrophisation des eaux des lacs (Modifications biologiques résultant de l’enrichissement des eaux de surface en phosphore). Proceedings of the Fourth International IMPHOS Conference: Phosphorus, Life and Environment. From Research to Application, Ghent, Belgium, 8-11 September 1992, pp. 361-371.

 

Barroin, G. (1999) Limnologie Appliquée au Traitement des Lacs et des Plans d’Eau. Les études des Agences de l’Eau no.62, Paris, pp. 35-40.

 

Bartholomew, B. et Hill, M.J. (1984) The pharmacology of dietary nitrate and the origin of urinary nitrate. Food and Chemical Toxicology 22, 789-795.

 

Barton, G.M.G. (1954) A fatal case of sodium nitrite poisoning. Lancet 1, 190-191.

 

Battaglia, C., Giulini, S., Regnani, G., Di Girolamo, R., Paganelli, S., Facchinetti, F. et Volpe, A. (2000) Seminal plasma nitrite/nitrate and intratesticular Doppler flow in fertile and infertile subjects. Human Reproduction 15, 2554-2558.

 

Beckman, J.S. et Koppenol, W.H. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. American Journal of Physiology 271 (Cell Physiology 40): C 1424-C 1437.

 

Beilin, L.J. (1994) Vegetarian and other complex diets, fats, fiber, and hypertension. American Journal of Clinical Nutrition 59 (suppl.) 1130S-1135S.

 

Belmont, H.M., Levartovsky, D., Amin, A.R., Skovron, M.L., Buyon, J., Giorno, R., Rediske, J. et Abramson, S.B. (1995) Upregulated expression of inducible nitric oxide synthase in SLE: evidence for activated endothelium. Arthritis and Rheumatism 38 (suppl. 9): S 390.

 

Benjamin, N. et Dykhuizen, R. (1999) Nitric oxide and epithelial host defence. In: Fang, F.C. (ed.) Nitric Oxide and Infection. Kluwer Academic/Plenum Publishers, New-York, pp. 215-230.

 

Benjamin, N. et McKnight, G. (1999) Metabolism in nitrate in humans - implications for nitrate intake. In: Wilson, W.S., Ball, A.S. et Hinton, R.H. (eds) Managing Risks of Nitrates to Humans and the Environment. The Royal Society of Chemistry, Cambridge, UK, pp. 281-288.

 

Benjamin, N., O’Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M. et Mc Kenzie, H. (1994) Stomach NO synthesis. Nature 368, 502.

 

Benjamin, N., Pattullo, S., Weller, R., Smith, L. et Ormerod, A. (1997) Wound licking and nitric oxide. Lancet 349, 1776.

 

Beresford, S.A.A. (1985) Is nitrate in the drinking water associated with the risk of cancer in the urban U.K.? International Journal of Epidemiology 14, 57-63.

 

Berlin, C.M. (1970) The treatment of cyanide poisoning in children. Pediatrics 46, 793-796.

 

Binder, H.J. et Sandle, G.I. (1987) Electrolyte absorption and secretion in the mammalian colon. In: Johnson, L.R., Christensen, J. Jackson, M.J., Jacobsen, E.D. et Walsh, J.H. (eds) Physiology of the Gastrointestinal Tract, 2nd edn., Raven Press, New York, pp. 1389-1418.

 

Binkerd, E.F. et Kolari, O.E. (1975) The history and use of nitrate and nitrite in the curing of meat. Food and Cosmetics Toxicology 13, 655-661.

 

Black, C.A. (1989) Reducing American Exposure to Nitrate, Nitrite, and Nitroso Compounds: the National Network to Prevent Birth Defects Proposal. Comments from CAST 1989-1. Council for Agricultural Science and Technology, Ames, Iowa, 14 pp.

 

Blaser, M.J. (1996) The bacteria behind ulcers. Scientific American 274, 92-97.

 

Block, G. (1991) Epidemiologic evidence regarding vitamin C and cancer. American Journal of Clinical Nutrition 54, 1310S-1314S.

 

Blum, M., Yachnin, T., Wollman, Y., Chernihovsky, T., Peer, G., Grosskopf, I., Kaplan, E., Silverberg, D., Cabili, S. and Iaina, A. (1998) Low nitric oxide production in patients with chronic renal failure. Nephron 79, 265-268.

 

Böckman, O.C. et Bryson, D.D. (1989) Well-water methaemoglobinaemia: the bacterial factor. In: Wheeler, D., Richardson, ML. et Bridges, J. (eds.) Watershed 89. The Future for Water Quality in Europe. Proceedings of the IAWPRC Conference, Guildford, UK. Pergamon Press. Oxford. Vol. 2, pp. 239-244.

 

Böckman, O.C. et Granli, T. (1991) Human health aspects of nitrate intake from food and water. In: Richardson, M.L. (ed.) Chemistry, Agriculture and the Environment. Royal Society of Chemistry, London, pp 373-388.

 

Böckman, O.C., Dahl, R., Johansen, T.E.B., Strand, O.A., Tacket, C.O. et Granli, T. (1996) Normal and abnormal rates of nitrate excretion in humans. In: Moncada, S., Stamler, J., Gross, S. et Higgs, E.A. (eds.) The Biology of Nitric Oxide, Part 5. Portland Press, London, 42 pp.

 

Böckman, O.C., Mortensen, B., Strand, O.A. et Leone, A. (1999) Ingestion of nitrate increase blood content of S-nitrosothiols, Acta Physiologica Scandinavica 167, Suppl. 645, 56, 138 ; also in: Moncada, S., Gustafsson, L.E., Wiklund, N.P. et Higgs, E.A. (eds) The Biology of Nitric Oxide, Part 7. Portland Press, London, 112 pp.

 

Bode A. (1997) Metabolism of vitamin C in health and disease. Advances in Pharmacology 18, 21-47.

 

Bode-Böger, S.M., Böger, R.H., Schröder, E.P. et Frölich, J.C. (1994) Exercise increases systemic nitric oxide production in men. Journal of Cardiovascular Risk 1, 173-178.

 

Boeing, H., Frentzel-Beyme, R., Berger, M., Berndt, V., Göres, W., Körner, M., Lohmeier, R., Menarcher, A., Männl, H.F.K., Meinhardt, M., Müller, R., Ostermeier, H., Paul, F., Schwemmle, K., Wagner, K.H. et Wahrendorf, J. (1991) Case-control study on stomach cancer in Germany. International Journal of Cancer 47, 858-864.

 

Boeing, H., Schlehofer, B., Blettner, M. et Wahrendorf, J. (1993) Dietary carcinogens and the risk for glioma and meningioma in Germany. International Journal of Cancer 53, 561-565.

 

Boivin, P. (1994) Structures, métabolisme et physiologie des globules rouges humains. Editions techniques. Encyclopédie Médico-chirurgicale. Paris. 13 000-R 10, 14 pp.

 

Bonell, A.E. (1995) Nitrate concentrations in vegetables. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite). Bilthoven (Netherlands) 8-10 November 1994. Council of Europe Press, Strasbourg, pp. 11-20.

 

Borneff, M. (1986) Der nitrategehalt des trinkwassers und das krankheitsbild der methaemoglobinaemie-kritische analyse einer kontroverse. Pro Aqua Pro Vita 10th Meeting. Basel, 3, pp 1-15.

 

Bos, P.M.J., Van Den Brandt, P.A., Wedel, M. et Ockhuizen, T. (1988) The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load. Food and Chemical Toxicology 26, 93-97.

 

Bosch, H.M., Rosenfield, A.B., Huston, R., Shipman, H.R. et Woodward, F.L. (1950) Methemoglobinemia and Minnesota well supplies. Journal, American Water Works Association 42, 161-170.

 

Boulaine, J. (1996) Histoire de l’Agronomie en France, 2ème édition. Lavoisier, Paris, 437 pp.

 

Bousset, J. et Fournaud, J. (1976) L’emploi des nitrates et des nitrites pour le traitement des produits carnés: aspects technologiques et microbiologiques. Annales de la Nutrition et de l’Alimentation 30, 707-714.

 

Boycott, A.E. (1911) Infective methaemoglobinaemia in rats caused by Gaertner’s bacillus. Journal of Hygiene 11, 443-472.

 

Bradberry, S.M., Gazzard, B. et Vale. J.A. (1994) Methemoglobinemia caused by the accidental contamination of drinking water with sodium nitrite. Clinical Toxicology 32, 173-178.

 

Brady J. (1991) The Coldest War. A Memoir of Korea. Pocket Books, New York, pp. 234-235.

 

Bricker, T., Jefferson, L.S. et Mintz, A.A. (1983) Methemoglobinemia in infants with enteritis. Journal of Pediatrics 102, 161.

 

Brown, M.A., Tibben, E., Zammit, V.C., Cario, G.M. et Carlton, M.A. (1995) Nitric oxide excretion in normal and hypertensive pregnancies. Hypertension in Pregnancy 14, 319-326.

 

Bruijns, E. (1982). Treatment of kidney stones with ammonium nitrate. Thesis, University of Nijmegen, The Netherlands (en hollandais, résumé en anglais).

 

Brunelli, L., Crow, J.P., et Beckman, J.S. (1995) The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli. Archives of Biochemistry and Biophysics 316, 327-334.

 

Bruning-Fann, C.J. et Kaneene, J.B. (1993) The effects of nitrate, nitrite and N-nitroso compounds on human health: a review. Veterinary and Human Toxicology 35, 521-538.

 

Buiatti, E., Palli, D., Decarli, A., Amadori, D., Avellini, C., Blanchi, S., Bonaguri, C., Cipriani, F., Cocco, P., Giacosa, A., Marubini, E., Minacci, C., Puntoni, R., Russo, A., Vindigni, C., Fraumeni, J.F. et Blot W.J. (1990) A case-control study of gastric cancer and diet in Italy: II Association with nutrients. International Journal of Cancer 45, 856-901.

 

Buson, C. (1999) Faut-il encore avoir peur des nitrates?. Fusion n° 75, 30-38.

 

Carcillo, J.A. (1999) Nitric oxide production in neonatal and pediatric sepsis. Critical Care Medicine 27, 1063-1065.

 

Carvalho, A.F., Fiorelli, L.A., Jorge, V.C.N., Da Silva, C.M.F., De Nucci, G., Ferraz, J.G.P. et Pedrazzoli, J. (1998) Addition of bismuth subnitrate to omeprazole plus amoxycillin improves eradication of Helicobacter pylori. Alimentary Pharmacology and Therapeutics 12, 557-561.

 

Cassens, R.G. (1990) Nitrite-cured Meat: a Food Safety Issue in Perspective. Food and Nutrition Press, Trumbull, Connecticut, 174 pp.

 

Catani, M.V., Bernassola, F., Rossi, A. et Melino, G. (1998) Inhibition of clotting factor XIII activity by nitric oxide. Biochemical and Biophysical Research Communications 249, 275-278.

 

Catel, W. et Tunger, H. (1933) Über das Vorkommen von nitrat (und nitrit) im harn junger saülinge bei ausschliesslicher frauenmilchernährung. Jahrbuch für Kinderheilkunde 140, 254-262.

 

Cave, D.R. (1996) Transmission and epidemiology of Helicobacter pylori. American Journal of Medicine 100 (suppl. 5 A), 12 S-18 S.

 

Caygill, C.P.J., Bartholomew, B. et Hill, M.J. (1986) The relation between drinking water nitrate and total nitrate intake. Aqua 2, 94-97.

 

Center for the Biology of Natural Systems (1973) A study of certain ecological, public health and economic consequences of the use of inorganic nitrogen fertilizer. Washington University, St Louis, Missouri.

 

Chapin, F.J. (1947) Methemoglobinemia from nitrates in well water. Journal of the Michigan State Medical Society 46, 938.

 

Charras, M. (1676) Pharmacopée Royale Galénique et Chymique.

 

Chen, J., Ohshima, H., Yang, H., Li, J., Campbell, T.C., Peto, R. et Bartsch, H. (1987) A correlation study on urinary excretion of N-nitroso compounds and cancer mortality in China: interim results.In: Bartsch, H., O'Neill, I.K. et Schulte-Hermann, R. (eds), Relevance of N-nitroso Compounds to Human Cancer: Exposures and Mechanisms. IARC Scientific Publications 84, Lyon, France, pp.503-506.

 

Chhabra, S.K., Souliotis, V.L., Kyrtopoulos, S.A. et Anderson, L.M. (1996) Nitrosamines, alcohol, and gastrointestinal tract cancer: recent epidemiology and experimentation. In Vivo 10, 265-284.

 

Chiaudani, G., Marchetti, R. et Vighi, M. (1980) Eutrophication in Emilia-Romagna coastal waters (North Adriatic Sea, Italy): a case history. Progress in Water Technology 12, 185-192.

 

Cicinelli, E., Ignarro, L.J., Lograno, M., Galantino, P., Balzano, G. et Schönauer, L.M. (1996) Circulating levels of nitric oxide in fertile women in relation to the menstrual cycle. Fertility and Sterility 66, 1036-1038.

 

Cicinelli, E., Ignarro, L.J., Schönauer, L.M., Matteo, M.G., Galantino, P. et Balzano, G. (1998) Effects of short-term transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women. Fertility and Sterility 69, 58-61.

 

Cicinelli, E., Ignarro, L.J., Matteo, M.G., Galantino, P., Schönauer, L.M. et Falco, N. (1999) Effects of estrogen replacement therapy on plasma levels of nitric oxide in postmenopausal women. American Journal of Obstetrics and Gynecology 180, 334-339.

 

Clark, R.S.B., Kochanek, P.M., Obrist, W.D., Wong, H.R., Billiar, T.R., Wisniewski, S.R. and Marion D.W. (1996) Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. Critical Care Medicine 24, 1243-1251.

 

Classen, H.G., Stein-Hammer, C. et Thöni, H. (1990) Hypothesis: The effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite? Journal of the American College of Nutrition 9, 500-502.

 

Clough, P.W.L. (1983) Nitrates and gastric carcinogenesis. Minerals and the Environment 5, 91-95.

 

Cohen, M. et Baghavan, N. (1995) Ascorbic acid and gastrointestinal cancer. Journal of the American College of Nutrition 14, 565-578.

 

Collier, D. et Benjamin, N. (1998) Nitrate and travellers’ diarrhoea. In: Moncada, S., Toda, N., Maeda, H. et Higgs, E.A. (eds) The Biology of Nitric Oxide Part 6. Proceedings of the 5th International Meeting of the Biology of Nitric Oxide, September 1997, Kyoto, Japan. Portland Press, London, p. 326.

 

Colosanti, M., Persichini, T., Venturini, G. et Ascenzi, P. (1999) S-nitrosylation of viral proteins: molecular bases for antiviral effect of nitric oxide. IUBMB Life 48, 25-31.

 

Comly, H.H. (1945) (1987) Cyanosis in infants caused by nitrates in well water. Journal of the American Medical Association 129, 112-116 et 257, 2788-2792.

 

Conrad, K.P., Joffe, G.M., Kruszyna, H., Kruszyna, R., Rochelle, L.G., Smith, R.P., Chavez, J.E. et Mosher, M.D. (1993) Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB Journal 7, 566-571

 

Cornblath, M. et Hartmann, A.F. (1948) Methemoglobinemia in young infants. Journal of Pediatrics 33, 421-425.

 

Corré, W.J. et Breimer, T. (1979) Nitrate and Nitrite in Vegetables. Centre for Agricultural Publishing and Documentation, Wageningen, 85 pp.

 

Correa, P. (1992) Human gastric carcinogenesis: a multistep and multifactorial process – First American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Research 52, 6735-6740.

Correa, P., Haenszel, W., Coello, C., Archer, M. et Tannenbaum, S.R. (1975) A model for gastric cancer epidemiology. Lancet, July 12 (7924), 58-60.

 

Cortas, N.K. et Wakid, N.W. (1991) Pharmacokinetic aspects of inorganic nitrate ingestion in man. Pharmacology and Toxicology 68, 192-195.

 

Cottrell, R. (1987) Nitrate in water. Nutrition and Food Science  106, 20-21.

 

Csanady, M. et Straub, I. (1995) Health damage due to water pollution in Hungary. In: Reichard, E.G. et Zapponi, A.G. (eds) Assessing and Managing Health Risks from Drinking Water Contamination: Approaches and Applications. Proceedings of a symposium held in Rome. International Association of Hydrological Sciences (IAHS) Press, Wallingford, UK, pp. 147-152.

 

Cuello, C., Correa, P., Haenszel, W., Gordillo, G., Brown, C., Archer, M. et Tannenbaum, S. (1976) Gastric cancer in Colombia: I Cancer risk and suspect environmental agents. Journal of the National Cancer Institute 57, 1015-1020.

 

Curtis, N.E., Gude, N.M., King, R.G., Marriott, P.J., Rook, T.J. et Brennecke, S.P. (1995) Nitric oxide metabolites in normal human pregnancy and preeclampsia. Hypertension in Pregnancy 14, 339-349.

 

Dang Vu, B., Paul, J.L., Gaudric, M., Guerre, J., Yonger, J. et Ekindjian, O.G. (1994) N-nitroso compounds, nitrite and pH in human fasting gastric juice. Carcinogenesis 15, 2657-2659.

 

Danish National Agency of Environmental Protection (1984) Quality criteria for certain substances in drinking water. Guidance document n°2, p 37 (en danois).

 

Davidge, S.T., Stranko, C.P. et Roberts, J.M. (1996) Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia. American Journal of Obstetrics and Gynecology 174, 1008-1013.

 

Davies, J.M. (1980) Stomach cancer mortality in Worksop and other Nottinghamshire mining towns. British Journal of Cancer 41, 438-445.

 

Davis, B.D., Dulbecco, R., Eisen, H.N. et Ginsberg, H.S. (1990) Microbiology, 4th edn. J.B.Lippincott Company, Philadelphia, pp. 730-732.

 

De Beer, J., Heyndrickx, A. et Timperman, J. (1975) Suicidal poisoning by nitrite. European Journal of Toxicology 8, 247-251.

 

Debreyne, P. (1846) Thérapeutique Appliquée et Traitements Spéciaux. J.B. Baillière, Paris.

 

Delwiche, C.C. (1970) The nitrogen cycle. Scientific American 223, 137-146.

 

Department of the Environment (1985) New standards for drinking water quality. Press notice 363 (23 July 1985), London.

 

Derache, R. et Derache P. (1997) Ion nitrate et oxyde nitrique NO en nutrition et en toxicologie. Cahiers de Nutrition et de Diététique 32,283-293.

 

Desai, K.M., Sessa, W.C et Vane, J.R. (1991) Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 351, 477-479.

 

Diagonale des Nitrates (1991). Etudes sur la Teneur en Nitrates de l’Alimentation. Ministère des Affaires Sociales et de l’Intégration. Edition Adheb, le Rheu, France, 21 pp.

 


 

Diem K. (ed.) (1963) Tables Scientifiques, 6ème edn. Documenta Geigy, Basel, 594 pp.

 

Donahoe, W.E. (1949) Cyanosis in infants with nitrates in drinking water as cause. Pediatrics 3, 308-311.

 

Dondorp, A.M., Planche, T., De Bel, E.E., Angus, B.J., Chotivanich, K.T., Silamut, K., Romijn, J.A., Ruangveerayuth, R., Hoek, F.J., Kager, P.A., Vreeken, J. et White, N.J. (1998) Nitric oxides in plasma, urine, and cerebrospinal fluid in patients with severe falciparum malaria. American Journal of Tropical Medicine and Hygiene 59, 497-502.

 

Dorsch, M.M., Calder, I.C., Roder, D.M. et Esterman, A.J. (1984a) Birth defects and the consumption of nitrates in food and water in the lower south-east of South Australia: an exploratory study. Journal of Food and Nutrition 41, 30-33.

 

Dorsch, M.M., Scragg, R.K.R., McMichael, A.J., Baghurst, P.A. et Dyer K.F. (1984b) Congenital malformations and maternal drinking water supply in rural South Australia: a case-control study. American Journal of Epidemiology 119, 473-486.

 

Dougall, H.T., Smith, L., Duncan, C. et Benjamin, N. (1995) The effect of amoxycillin on salivary nitrite concentrations: an important mechanism of adverse reactions?. British Journal of Clinical Pharmacology 39, 460-462.

 

Duby, J.J. (1998) Risque alimentaire et désinformation. In: Risques et Peurs Alimentaires. Odile Jacob, Paris, pp 159-165.

 

Dudley, N. (1990) Nitrates. The Threat to Food and Water. Green Print, London, 118 pp.

 

Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R. , Leifert, C., Smith, L., Golden, M. et Benjamin, N. (1995) Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nature Medicine 1, 546-551.

 

Duncan C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., McKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., Kelly, D., Golden, M., Benjamin, N. et Leifert, C. (1997) Protection against oral and gastro-intestinal diseases: importance of dietary nitrate intake, oral nitrate reduction and enterosalivary circulation. Comparative Biochemistry and Physiology 119A, 939-948.

 

Dupeyron, J.P., Monier, J.P. et Fabiani, P. (1970) Nitrites alimentaires et méthémoglobinémies du nourrisson. Annales de Biologie Clinique 28, 331-336.

 

Dupont, C. and Benhamou, P.H. (1993) Traitement de la diarrhée aiguë de l’enfant. In: Progrès en hépatogastroentérologie 8. Diarrhées aiguës infectieuses. Doin, Paris, pp. 157-170.

 

Dusdieker, L.B., Getchell, J.P., Liarakos, T.M., Hausler, W.J. et Dungy, C.I. (1994) Nitrate in baby foods. Adding to the nitrate mosaic. Archives of Pediatrics and Adolescent Medicine, 148, 490-494.

 

Dusdieker, L.B., Stumbo, P.J., Kross, B.C. et Dungy, C.I. (1996) Does increased nitrate ingestion elevate nitrate levels in human milk?. Archives of Pediatrics and Adolescent Medicine 150, 311-494.

 

Dutt, M.C., Lim, H.Y. et Chew, R.K.H. (1987) Nitrate consumption and the incidence of gastric cancer in Singapore. Food and Chemical Toxicology 25, 515-520.

 

Dykhuizen, R.S., Copland, M., Smith, C.C., Douglas, G. et Benjamin N. (1995) Plasma nitrate concentration and urinary nitrate excretion in patients with gastro-enteritis. Journal of Infection 31, 73-75.

 


Dykhuizen, R.S., Frazer, R., Duncan, C., Smith, C.C., Golden, M., Benjamin, N. et Leifert, C. (1996) Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defence. Antimicrobial Agents and Chemotherapy 40, 1422-1425.

 

Dykhuizen, R.S., Fraser, A., McKenzie, H., Golden, M., Leifert, C. et Benjamin N. (1998) Helicobacter pylori is killed by nitrite under acidic conditions. Gut 42, 334-337.

 

Eardley, I. (1997) The role of phosphodiesterase inhibitors in impotence. Expert Opinion on Investigational Drugs 6, 1803-1810.

 

ECETOC (1988) Nitrate and Drinking Water Technical report no. 27. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, 165 pp.

 

Edgar, W.M. (1992) Saliva: its secretion, composition and functions British Dental Journal 172, 305-312.

 

Egberts, J., van Den Bosch, N. et Brand, R. (1999) Nitric oxide metabolites, cyclic guanosine 3’, 5’ monophosphate and dimethylarginines during and after uncomplicated pregnancies: a longitudinal study. European Journal of Obstetrics and Gynecology and Reproductive Biology 82, 35-40.

 

Eichholzer, M. et Gutzwiller, F. (1998) Dietary nitrates, nitrites, and N-nitroso compounds and cancer risk: a review of the epidemiological evidence. Nutrition Reviews 56, 95-105.

 

Eisenbrand, G., Spiegelhalder, B. et Preussmann, R. (1980) Nitrate and nitrite in saliva. Oncology 37, 227-231

 

Ellen, G. et Schuller, P.L. (1983) Nitrate, origin of continuous anxiety. In: Preusmann, R. (ed.) Das Nitrosamin-Problem. Deutsche Forschungsgemeinschaft, Verlag Chemie GmbH, Weinheim, pp. 97-134.

 

Ellen, G., Schuller, P.L., Bruijns, E., Froeling, P.G.A.M. et Bradenhuijsen, H. (1982a) Volatile N-nitrosamines, nitrate and nitrite in urine and saliva of healthy volunteers after administration of large amounts of nitrate. In: Bartsch, H., Castegnaro, M., O’Neil, I.K. et Okada, M. (eds.) N-nitrosocompounds: Occurrence and Biological Effects. IARC Scientific Publications 41, Lyon, France. pp. 365-378.

 

Ellen, G., Schuller, P.L., Froeling, P.G.A.M. et Bruijns, E. (1982b) No volatile N-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate. Food and Chemical Toxicology 20, 879-882.

 

Ellis, G., Adatia, I., Yazdampanah, M. et Makela, S.K. (1998) Nitrite and nitrate analyses: a clinical biochemistry perspective. Clinical Biochemistry 31, 195-220.

 

Ellis, M., Hiss, Y. et Shenkman, L. (1992) Fatal methemoglobinemia caused by inadvertent contamination of a laxative solution with sodium nitrite. Israel Journal of Medicine Science 28, 289-291.

 

Emmett, W. and Son Ltd. (1998) Nitrates in spinach: results of screening and investigations. Company report, W. Emmett & Son Ltd., Byfleet, Surrey, August 1998, 25 pp.

 

EPA (1990) Drinking water criteria document on nitrate/nitrite. Prepared by Life Systems Inc., Cleveland, OH, for the Environment Protection Agency, Criteria and Standards Division, Office of Drinking Water. Washington, DC.

 

EU (1980) Council Directive 80/778/EEC of 15 July 1980 on the quality of drinking water intended for human consumption. Official Journal L 229, 30/08/1980, 11-26.

 

EU (1983) Commission of the European Communities. Report of the Scientific Committee for food on essential requirements of infant formulae and follow-up milk based on cow’s milk proteins (14th series, Cat. No. EUR 8752). Opinion expressed on the 27 April 1983.

 

EU (1991a) Commission of the European Communities. First report of the Scientific Committee for Food on the Essential Requirements for Weaning Foods (24th series, Cat.No. EUR 13140). Opinions expressed on the 27 October 1989 and 30 March 1990.

 

EU (1991b) Council Directive 91/676/EEC of 12 December 1991 concerning the protection of waters against pollution caused by nitrates from agricultural sources. Official Journal L 375, 31/12/1991, 1-8.

 

EU (1992) Commission of the European Communities. Report of the Scientific Committee for Food on nitrates and nitrites (26th series). Opinion expressed on 19 October 1990, 21-29.

 

EU (1995a) European Parliament and Council Directive 95/2/EC of 20 February 1995 on food additives other than colours and sweeteners. Official Journal L61, 18/3/1995, 1-40.

 

EU (1995b) European Commission Directorate-General III Industry. Scientific Committee for Food. Opinion on nitrate and nitrite expressed on 22 September 1995. Annex 4 to Document III/5611/95.

 

EU (1997) Commission Regulation (EC) No. 194/1997 of 31 January 1997 setting maximum levels for certain contaminants in foodstuffs. Official Journal L031, 1/2/1997, 48-50.

 

EU (1998) Council Directive 98/83/EC of 3 November 1998 on the quality of water intended for human consumption. Official Journal L330, 05/12/1998, 32-54.

 

EU (1999) Commission Regulation (EC) No. 864/1999 of 26 April 1999, Amending regulation (EC) No. 194/97 setting maximum levels for certain contaminants in foodstuffs. Official Journal L108, 16-18.

 

Eusterman, G.B. et Keith, N.M. (1929) Transient methemoglobinemia following administration of ammonium nitrate. Medical Clinics of North America 12, 1489-1496.

 

Ewing, M.C. et Mayon-White, R.M. (1951) Cyanosis in infancy from nitrates in drinking water. Lancet 260, 931-934.

 

Fan, A.M. et Steinberg, V.E. (1996) Health implications of nitrate and nitrite in drinking water: an update on methemoglobinemia occurrence and reproductive and developmental toxicity. Regulatory Toxicology and Pharmacology 23, 35-43.

 

Fandre, M., Coffin, R., Dropsy, G. et Bergel, J.P. (1962) Epidémie de gastro-entérite à Escherichia coli 0 127 B8 avec cyanose méthémoglobinémique. Archives Françaises de Pédiatrie 19, 1129-1131.

 

Fandrem, S.I., Kjuus, H., Andersen, A. et Amlie, E. (1993) Incidence of cancer among workers in a Norwegian nitrate fertiliser plant. British Journal of Industrial Medicine 50, 647-652.

 

Feinstein, A.R. (1997) Biases introduced by confounding and imperfect retrospective and prospective exposure assessments. In: Bate, R. (ed.) What risk? Science, Politics and Public Health. Butterworth – Heinemann, Oxford, UK, pp. 37-48.

 

Filer, L.J., Lowe, C.U., Barness, L.A., Goldbloom, R.B., Heald, F.P., Holliday, M.A., Miller, R.W., O’Brien, D., Owen, G.M., Pearson, H.A., Scriver, C.R., Weil, W.B., Kine, O.L., Cravioto, J. et Whitten, C. (American Academy of Pediatrics; Committee on nutrition) (1970) Infant methemoglobinemia ; the role of dietary nitrate. Pediatrics 46, 475-477.

 

Finan, A., Keenan, P., O’Donovan, F., Mayne, P. et Murphy, J. (1998) Methaemoglobinaemia associated with sodium nitrite in three siblings. British Medical Journal 317, 1138-1139.

 

Florin, T.H.J., Neale, G. et Cummings, J.H. (1990) The effect of dietary nitrate on nitrate and nitrite excretion in man. British Journal of Nutrition 64, 387-397.

 

Forman, D. (1991) Nitrate exposure and human cancer. In: Bogardi, I. et Kuzelka, R.D. (eds.) Nitrate Contamination Exposure Consequence and Control. NATO ASI Series G30, Springer-Verlag, Berlin, pp 281-288.

 

Forman, D., Al.-Dabbagh, S. et Doll, R. (1985) Nitrates, nitrites and gastric cancer in Great Britain. Nature 313, 620-625.

 

Forman, D., Leach, S., Packer, P., Davey, G. et Heptonstall, J. (1992) Significant endogenous synthesis of nitrate does not appear to be a feature of influenza A virus infection. Cancer Epidemiology, Biomarkers and Prevention 1, 369-373.

 

Forte, P., Copland, M., Smith, L.M., Milne, E., Sutherland, J. et Benjamin, N. (1997) Basal nitric oxide synthesis in essential hypertension. Lancet 349, 837-842.

 

Forte, P., Dykhuizen, R.S., Milne, E., McKenzie, A., Smith, C.C. et Benjamin, N. (1999) Nitric oxide synthesis in patients with infective gastroenteritis. Gut 45, 355-361.

 

Fraser, P. et Chilvers, C. (1981) Health aspects of nitrate in drinking water. The Science of the Total Environment 18, 103-116.

 

Fraser, P., Chilvers, C., Day, M. et Goldblatt, P. (1989) Further results from a census based mortality study of fertiliser manufacturers. British Journal of Industrial Medicine 46, 38-42.

 

Fritsch, P., de Saint-Blanquat, G., Derache, R. et Canal, M.T. (1979) Cinétique de l’absorption intestinale, chez le rat, des nitrates et des nitrites. Toxicological European Research (Puteaux) 3, 141-147.

 

Fritsch, P., Canal, M.T. et de Saint Blanquat, G. (1983) Expérience en pair-feeding chez des rats traités au nitrate ou au nitrite de sodium. Annals of Nutrition and Metabolism 27, 38-47.

 

Fritsch, P., de Saint Blanquat, G. et Klein, D. (1985) Excretion of nitrates and nitrites in saliva and bile in the dog. Food and Chemical Toxicology 23, 655-659.

 

Froeling, P.G.A.M. et Prenen, H. (1977) Acute acid loads with different anions in patients with rental stones. Netherlands Journal of Medicine 20, 26-27.

 

Fytianos, K. et Zarogiannis, P. (1999) Nitrate and nitrite accumulation in fresh vegetables from Greece. Bulletin of Environmental Contamination and Toxicology 62, 187-192.

 

Gangolli, S.D., van den Brandt, P.A., Feron, V.J., Janzowsky, C., Koeman, J.H., Speijers, G.J.A., Spiegelhalder, B., Walker, R. et Wishnok, J.S. (1994) Nitrate, nitrite and N-nitroso-compounds. European Journal of Pharmacology, Environmental Toxicology and Pharmacology Section 292, 1-38.

 

Gatseva, P., Lazarova, A., Maximova, S. et Pavlova, K. (1996) Experimental data on the effect of nitrates entering the organism with the drinking water. Folia Medica 37, 75-83.

 

Gebara, B.M. and Goetting, M.G. (1994) Life-threatening methemoglobinemia in infants with diarrhea and acidosis. Clinical Pediatrics 33, 370-373.

 

Gelberg, K.H., Church, L., Casey, G., London, M., Roerig, D.S., Boyd, J. et Hill, M. (1999) Nitrate levels in drinking water in rural New York state. Environmental Research Section A 80, 34-40.

 

Geleperin, A., Moses, V.J.et Fox, G. (1976) Nitrate in water supplies and cancer. Illinois Medical Journal 149, 251-253.

 

Gendrin (1837) Note sur le traitement du rhumatisme articulaire aigu par le nitrate de potasse à haute dose. Journal de Médecine et de Chirurgie Pratiques. Imp. Decourchant, Article 1432, p. 115..

 

Genesca, J., Gonzalez, A., Segura, R., Catalan, R., Marti, R., Varela, E., Cardelina, G., Martinez, M., Lopez-Talavera, J.C., Esteban, R., Groszmann, R.J. et Guardia, J. (1999) Interlenkin-6, nitric oxide and the clinical and hemodynamic alterations of patients with liver cirrhosis. American Journal of Gastroenterology 94, 169-177.

 

Gilbert, A. et Yvon, P. (1911) Formulaire de Pratique et de Thérapeutique Pharmacologique. Doin, Paris.

 

Gilkeson, G., Cannon, C., Goldman, D. et Petri, M. (1996) Correlation of a serum measure of nitric oxide production with lupus disease activity measures. Arthritis and Rheumatism 39 (suppl. 9): S251.

 

Gilli, G., Corrao, C. et Favilli, S. (1984) Concentrations of nitrates in drinking water and incidence of gastric carcinomas: first descriptive study of the Piemonte Region, Italy. The Science of the Total Environment 34, 35-48.

 

Giovannoni, G., Heales, S.J.R., Silver, N.C., O’Riordan, J., Miller, R.F., Land, J.M., Clark, J.B. et Thompson, E.J. (1997a) Raised serum nitrate and nitrite levels in patients with multiple sclerosis. Journal of the Neurological Sciences 145, 77-81.

 

Giovannoni, G., Land, J.M., Keir, G., Thompson, E.J. et Heales, S.J.R. (1997b) Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Annals of Clinical Biochemistry 34, 193-198.

 

Giovannoni, G., Miller, R.F., Heales, S.J.R., Land, J.M., Harrison, M.J.G. et Thompson E.J. (1998) Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction. Journal of the Neurological Sciences 156, 53-58.

 

Giroux, M. et Ferrières, J. (1998) Serum nitrates and creatinine in workers exposed to atmospheric nitrogen oxides and ammonia. The Science and the Total Environment 217, 265-269.

 

Gonzalez, C.A., Riboli, E., Badosa, J., Batiste, E., Cardona, T., Pita, S., Sanz, J.M., Torrent, M. et Agudo, A. (1994) Nutritional factors and gastric cancer in Spain. American Journal of Epidemiology 139, 466-473.

 

Gonzalez-Crespo, M.R., Navarro, J.A., Arenas, J., Martin-Mola, E., De La Cruz, J. et Gomez-Reino, J.J. (1998) Prospective study of serum and urinary levels in patients with systemic lupus erythematosus. British Journal of Rheumatology 37, 972-977.

 

Gounelle De Pontanel, H., Astier-Dumas, M., Gulat-Marnay, C., Jacquet, J., Huynh Cong Hau, Boutibonnes, P., Custot, F. et Mezonnet, R. (1971) Problèmes hygiéniques posés par la carotte, particulièrement dans l’alimentation du jeune enfant (méthémoglobinémie, résidus d’insecticides). Bulletin de l’Académie Nationale de Médecine 155, 82-99.

 


Gowans, W.J. (1990) Fatal methemoglobinemia in a dental nurse. A case of sodium nitrite poisoning. British Journal of General Practice 40, 470-471.

 

Grabowski, P.S., England, A.J., Dykhuizen, R., Copland, M., Benjamin, N., Reid, D.M. et Ralston, S.H. (1996) Elevated nitric oxide production in rheumatoid arthritis. Detection using the fasting urinary nitrate: creatinine ratio – Arthritis and Rheumatism 39, 643-647.

 

Granli, T., Dahl, R., Brodin, P. et Böckman, O.C. (1989) Nitrate and nitrite concentrations in human saliva: variations with salivary flow-rate. Food and Chemical Toxicology 27, 675-80.

 

Grasemann, H., Ioannidis, I., De Groot, H. et Ratjen, F. (1997) Metabolites of nitric oxide in the lower respiratory tract of children. European Journal of Pediatrics 156, 575-578.

 

Grasemann, H., Ioannidis, I., Tomkiewicz, R.P., De Groot, H., Rubin, B.K. et Ratjen, F. (1998) Nitric oxide metabolites in cystic fibrosis lung disease. Archives of Disease in Childhood 78, 49-53.

 

Grasset, E. et Lestradet, H. (1987) Fonctions du côlon chez l’homme. Cahiers de Nutrition et de Diététique 22, 196-200.

 

Green, L.C., Ruiz de Luzuriaga, K., Wagner, D.A., Rand, W., Istfan, N., Young, V.R. et Tannenbaum, S.R. (1981) Nitrate biosynthesis in man. Proceedings of the National Academy of Sciences USA 78, 7764-7768.

 

Green, L.C., Tannenbaum, S.R. et Fox, J.G. (1982) Nitrate in human and canine milk. New England Journal of Medicine 306, 1367-1368.

 

Greenwood, D.J. et Hunt, J. (1986) Effect of nitrogen fertiliser on the nitrate contents of field vegetables grown in Britain. Journal of the Science of Food and Agriculture, Cambridge 37, 373-383.

 

Griess, P. (1878) Über Metadiamidobenzol als Reagens auf salpetrige Saüre. Berichte der Deutschen Chemischen Gesellschaft, 624-627.

 

Griffin, J.P. (1997) Methemoglobinemia. Adverse Drug Reactions and Toxicological Reviews 16, 45-63

 

Groenen, P.J., Pouw, H.J., Huis in’t Veld, J.H.J. et Theuns, H.M. (1988) Influence of oral microflora and dental status on intra-oral nitrate/nitrite conversion after nitrate ingestion. Report no. A 88.509, The Netherlands Organization for Applied Scientific Research. TNO-CIVO Institutes, 55 pp.

 

Gruener, N. et Toeplitz, R. (1975) The effect of changes in nitrate concentration in drinking water on methemoglobin levels in infants. International Journal of Environmental Studies 7, 161-163.

 

Guarner, C., Soriano, G., Tomas, A., Bulbena, O., Novella, M.T., Balanzo, J. Vilardell, F., Mourelle, M. et Moncada, S. (1993) Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 18, 1139-1143.

 

Gupta, S.K., Gupta, R.C., Gupta, A.B., Seth, A.K., Bassin, J.K. et Gupta, A. (2000a) Recurrent acute respiratory tract infections in areas with high nitrate concentrations in drinking water. Environmental Health Perspectives 108, 363-366.

 

Gupta, S.K., Gupta, R.C., Seth, A.K., Gupta, A.B., Bassin, J.K. et Gupta, A. (2000b) Methaemoglobinaemia in areas with nitrate concentration in drinking water. National Medical Journal of India 13, 58-61.

 

Haas, M., Classen, H.G., Thöni, H. Classen, U.G. et Drescher B. Persistent antihypertensive effect of oral nitrite supplied up to one year via the drinking water in spontaneously hypertensive rats. Arzneimittel–Forschung/Drug Research 49 (1), 318-323.

 

Hagmar, L., Bellander, T., Andersson, C., Linden, K., Attewell, R. et Möller, T. (1991) Cancer morbidity in nitrate fertilizer workers. International Archives of Occupational and Environmental Health 63, 63-67.

 

Haldane, J. (1901) The red color of salted meat. Journal of Hygiene (Cambridge) 1, 115.

 

Hanekamp, J.C. (1998) Nitrate and Public Health: an Overview. K. Beckman (ed.). A “Heidelberg Appeal Nederland” publication, 52 pp.

 

Hansson, L.-E., Nyren, O., Bergström, R., Wolk, A., Lindgren, A., Baron, J. et Adami, H.O. (1994) Nutrients and gastric cancer risk. A population-based case-control study in Sweden. International Journal of Cancer 57, 638-644.

 

Hanukoglu, A., Fried, D. et Bodner, D. (1983) Methemoglobinemia in infants with enteritis. The Journal of Pediatrics 102, 161-162.

 

Harada, M.,  Ishiwata, H., Nakamura, Y., Tanimura, A. et Ishidate, M. (1975) Studies on in vivo formation of nitroso compounds (I) Changes of nitrite and nitrate concentrations in human saliva after ingestion of salted Chinese cabbage. Journal of the Food Hygienic Society of Japan 16, 11-18.

 

Harper, R., Parkhouse, N., Green, C. et Martin, R. (1997) Nitric oxide production in burns: plasma nitrate levels are not increased in patients with minor thermal injuries. Journal of Trauma: Injury, Infection, and Critical Care 43, 467-474.

 

Harries, J.T. et Fraser, A.J. (1968) The acidity of the gastric contents of premature babies during the first fourteen days of life. Biologia Neonatorum 12, 186-193.

 

Harris, J.C., Rumack, B.H., Peterson, R..G. et McGuire, B.M. (1979) Methemoglobinemia resulting from absorption of nitrates. Journal of the American Medical Association 242, 2869-2871.

 

Hartman, P.E. (1982) Nitrates and nitrites: ingestion, pharmacodynamics, and toxicology. Chemicals Mutagens - Principles and Methods for their Detection 7, 211-294.

 

Hartman, P.E. (1983) Review: Putative mutagens and carcinogens in foods. I Nitrate/nitrite ingestion and gastric cancer mortality. Environmental Mutagenesis 5, 111-121.

 

Hausladen, A et Fridovich, I. (1994) Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. Journal of Biological Chemistry 269, 29405-29408.

 

Hecht, S.S. (1997) Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis. Proceedings of the Society for Experimental Biology and Medicine 216, 181-191.

 

Hecht, S.S. et Hoffmann, D. (1989) The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surveys 8, 273-294.

 

Hegesh, E. et Shiloah, J. (1982) Blood nitrates and infantile methemoglobinemia. Clinica Chimica Acta 125, 107-125.

 

Henretig, F.M., Gribetz, B., Kearney, T., Lacouture, P. et Lovejoy, F.H. (1988) Interpretation of color change in blood with varying degree of methemoglobinemia. Clinical Toxicology 26, 293-301.

 

Hibbs, J.B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowsk, R.L., Ward, J.H., Menlove, R.L., McMurry, P.P., Kushner, J.P. et Samlowski, W.E. (1992) Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin–2 therapy. Journal of Clinical Investigation 89, 867-877.

 

Hill, M.J. (1991a) Bacterial N-nitrosation and gastric carcinogenesis in humans. Italian Journal of Gastroenterology 23, 17-23.

 

Hill, M.J. (1991b) Nitrates and nitrites from food and water in relation to human disease. In: Hill, M. (ed.) Nitrates and Nitrites in Food and Water. Ellis Horwood, Chichester, UK, pp. 163-193.

 

Hill, M.J. (1999) Nitrate toxicity: myth or reality? British Journal of Nutrition 81, 343-344.

 

Hill, M.J. et Hawksworth, G. (1974) Some studies on the production of nitrosamines in the urinary bladder and their subsequent effects. In: Bogorski, P. et Walker, E.A. (eds) N-nitroso-Compounds in the Environment. IARC Scientific Publications 9, Lyon, France, pp. 220-222.

 

Hoidal, C.R., Hall, A.H., Robinson, M.D., Kulig, K. et Rumack, B.H. (1986) Hydrogen sulfide poisoning from toxic inhalations of roofing asphalt fumes. Annals of Emergency Medicine 15, 826-830.

 

Hölscher, P.M. et Natzschka, J. (1964) Methämoglobinämie bei jungen Saunglingen durch nitrithaltigen Spinat. Deutsche Medizinische Wochenschrift 89, 1751-1754.

 

Holtan-Hartwig, L. et Böckman, O.C. (1994) Ammonia exchange between crops and air. Norwegian Journal of Agricultural Sciences, Suppl. 14, 1-41.

 

Höring, H., Dobberkau, H.-J. et Seffner, W. (1988) Antithyreoidale umweltchemikalien. Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 34, 170-173.

 

Hornung, W. (1999) The role of nitrates in the eutrophication and acicfication of surface waters. In: Wilson, W.S., Ball, A.S. et Hinton, R.H. (eds) Managing Risks of Nitrates to Humans and the Environment. The Royal Society of Chemistry, Cambridge, UK, pp. 155-174.

 

Hotchkiss, J.H. (1988) Nitrate, nitrite balance, and de novo synthesis of nitrate. American Journal of Clinical Nutrition 47, 161-162.

 

House of Lords (1989) Nitrate in water. Select Committee on the European Communities. 16th report. HMSO, London. 51 pp.

 

Hovenga, S., Koenders, M.E.F., Van Der Werf, T.S., Moshage, H. et Zijlstra, J.G. (1996) Methaemoglobinaemia after inhalation of nitric oxide for treatment of hydrochlorothiazide-induced pulmonary oedema. Lancet 348, 1035-1036.

 

Hsu, C.-D., Aversa, K., Meaddough, E., Lee, I.-S. et Copel, J.A. (1997) Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3’, 5’ – monophosphate in pregnant women with intraamniotic infection. American Journal of Obstetrics and Gynecology 177, 793-796.

 

Hsu, C.-D., Aversa, K.R., Lu, L.C., Meaddough, E., Jones, D. Bahado-Singh, R.O., Copel, J.A. et Lee, I.S. (1999) Nitric oxide: a clinically important amniotic fluid marker to distinguish between intra-amniotic mycoplasma and non-mycoplasma infections. American Journal of Perinatology 16, 161-166.

 

Huang, C.-C. et Chu, N.-S. (1987) A case of acute hydrogen sulfide (H2S) intoxication successfully treated with nitrites. Journal of the Formosan Medical Association 86, 1018-1020.

 

Hudson, R.J.M., Gherini, S.A. et Goldstein, R.A. (1994) Modeling the global carbon cycle: nitrogen fertilization of the terrestrial biosphere and the “missing” CO2 sink. Global Biogeochemical Cycles 8, 307-333.

 

Hunt, J. et Turner, M.K. (1994) A survey of nitrite concentrations in retail fresh vegetables. Food Additives and Contaminants 11, 327-332.

 

Iizuka, T., Sasaki, M., Oishi, K., Uemura, S., Koike, M. et Minatogawa, Y. (1997) Nitric oxide may trigger lactation in humans. Journal of Pediatrics 131, 839-843.

 

Iizuka, T., Sasaki, M., Oishi, K., Uemura, S. et Koike, M. (1998) The presence of nitric oxide synthase in the mammary glands of lactating rats. Pediatrics Research 44, 197-200.

 

Iizuka, T., Sasaki, M., Oishi, K., Uemura, S., Koike, M. et Shinozaki, M. (1999) Non-enzymatic nitric oxide generation in the stomachs of breastfed neonates. Acta Paediatrica 88, 1053-1055.

 

Ikeda, H., Sato, I., Matsunaga, T., Takahashi, N., Yuasa, T. et Murota, S. (1995) Cyclic guanosine monophosphate (cGMP), nitrite and nitrate in the cerebrospinal fluid in meningitis, multiple sclerosis and Guillain-Barré syndrome. Internal Medicine 34, 734-737.

 

ISCWQT (International Standing Committee on Water Quality and Treatment) (1974) Nitrates in Water Supplies. Aqua 1, 5-25.

 

Iyengar, R., Stuehr, D.J. et Marletta, M.A. (1987) Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proceedings of the National Academy of Sciences USA 84, 6369-6373.

 

Jacobs, M.F. et Keith, N.M. (1926) The use of diuretics in cardiac edema. Medical Clinics of North America 10, 605-610.

 

Jaekle, R.K., Lutz, P.D., Rosenn, B., Siddiqi, T.A. et Myatt, L. (1994) Nitric oxide metabolites and preterm pregnancy complications. American Journal of Obstetrics and Gynecology 171, 1115-1119.

 

Janzowski, C. et Eisenbrand, G. (1995) Aspects to be considered for risk assessment concerning endogenously formed N-nitroso compounds. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite), Bilthoven (Netherlands), 8-10 November  1994. Council of Europe Press, Strasbourg, pp. 313-330.

 

Jarvis, S.C. (1999) Nitrogen dynamics in natural and agricultural ecosystems. In: Wilson, W.S., Ball, A.S. et Hinton, R.H. (eds) Managing Risks of Nitrates to Humans and the Environment, Royal Society of Chemistry, Cambridge, UK, pp. 2-20.

 

Jean-Louis, F., Fisher, J., Brodsky, N. et Hurt, H. (1993) Gastric pH in very low birth weight (VLBW) infants in the first postnatal week. Pediatric Research 33, 216 A.

 

Jensen, O.M. (1982) Nitrate in drinking water and cancer in Northern Jutland, Denmark, with special reference to stomach cancer. Ecotoxicology and Environmental Safety 6, 258-267.

 

Johnson, C.J. et Bonrup, P. (1988) Methemoglobinemia: is it coming back to haunt us? Health and Environment Digest 1, 3-4.

 

Johnson, C.J., Bonrud, P.A., Dosch, T.L., Kilness, A.W., Senger, K.A., Busch, D.C. et Meyer, M.R. (1987) Fatal outcome of methemoglobinemia in an infant. Journal of the Medical Association 257, 2796-2797.

 

Joint Iran-International Agency for Research on Cancer Study Group (1977) Esophageal cancer studies in the Caspian Littoral of Iran: results of population studies – a prodrome. Journal of the National Cancer Institute 59, 1127-1138.

 

Jolly, B.T., Monico, E.P. et Mc Devitt, B. (1995) Methemoglobinemia in an infant: case report and review of the literature. Pediatric Emergency Care 11, 294-297.

 

Joossens, J.V., Hill, M.J., Elliott, P., Stamler, R., Stamler, J., Lesaffre, E., Dyer, A., Nichols, R. et Kesteloot, H. (1996), on behalf of European Cancer Prevention (ECP) and the Intersalt Cooperative Research Group. Dietary salt, nitrate and stomach cancer mortality in 24 countries. International Journal of Epidemiology 25, 494-504.

 

Juhasz, L., Hill, M.J. et Nagy, G. (1980) Possible relationship between nitrate in drinking water and incidence of stomach cancer. In: Walker, E.A., Griciute, L., Castagnero, M. et Börzsöny, M. (eds) N-nitroso Compounds: Analysis, Formation and Occurrence. IARC Scientific Publications 31, Lyon, France, pp.619-623.

 

Jungersten, L., Edlund, A., Hafström, L.O., Karlsson, L., Petersson, A.S. et Wennmalm, A. (1993) Plasma nitrate as an index of immune system activation in animals and man. Journal of Clinical and Laboratory Immunology 40, 1-4.

 

Jungersten, L., Edlund, A., Petersson, A-S. et Wennmalm, A. (1996) Plasma nitrate as an index of nitric oxide formation in man: analyses of kinetics and confounding factors. Clinical Physiology 16, 369-379.

 

Kaarstad, O. (1997) Fertilizer’s significance for cereal production and cereal yield from 1950 to 1995. In: Mortvedt, J.J. (ed.) International Symposium on Fertilization and the Environment, Technicon-Israel Institute of Technology, Haife, Israel, pp. 56-64.

 

Kamiyama, J., Ohshima, H., Shimada, A., Saito, N., Bourgade, M.-C., Ziegler, P. et Bartsch, H. (1987) Urinary excretion of N-nitrosamino acids and nitrate by inhabitants in high- and low-risk areas for stomach cancer in northern Japan. In: Bartsch, H., O'Neill, I.K. et Schulte-Hermann, R. (eds) Relevance of N-nitroso Compounds to Human Cancer: Exposure and Mechanisms. IARC Scientific Publications 84, Lyon, France, pp. 497-502.

 

Kammerer, M. (1994) Etude expérimentale de la toxicité chronique de l’ion nitrate chez le lapin. Thèse de doctorat d’université. Faculté des sciences et des techniques, Université de Nantes. France.

 

Kammerer, M., Pinault, L. et Pouliquen H. (1992) Teneur en nitrate du lait. Relation avec sa concentration dans l’eau d’abreuvement. Annales de Recherches Vétérinaires 23, 131-138.

 

Kaplan, A., Smith, C., Promnitz, D.A., Joffe, B.I. et Seftel, H.C. (1990) Methaemoglobinaemia due to accidental sodium nitrite poisoning. South African Medical Journal 77, 300-301.

 

Kay, M.A., O’Brien, W.O., Kessler, B., McVie, R., Ursin, S., Dietrich, K. et McCabe, E.R.B. (1990) Transient organic aciduria and methemoglobinemia with acute gastroenteritis. Pediatrics 85, 589-592.

 

Keating, J.P., Lell, M.E., Strauss, A.W., Zarkowsky, H. et Smith, G.E. (1973) Infantile methemoglobinemia caused by carrot juice. New England  Journal of Medicine 288, 824-826.

 

Keith, N.M., Whelan, M. et Bannick, E.G. (1930) The action and excretion of nitrates. Archives of Internal Medicine 46, 797-832.

 

Kiese, M. (1974) Methemoglobinemia : a Comprehension Treatise. Causes, Consequences, and Correction of Increased Contents of Ferrihemoglobin in Blood. CRC Press, Cleveland, Ohio, 260 pp.

 

Kiese, M. et Weger, N. (1969) Formation of ferrihaemoglobin with aminophenols in the human for the treatment of cyanide poisoning. European Journal of Pharmacology 7, 97-105.

 

Kinzig, A.P. et Socolow R, H. (1994) Human impacts on the nitrogen cycle. Physics Today 47 (November) 24-31.

 

Kitagawa, H., Takeda, F. et Kohei, H. (1990) Effect of endothelium–derived relaxing factor on the gastric lesion induced by HCl in rats. Journal of Pharmacology and Experimental Therapeutics 253, 1133-1137.

 

Kleinjans, J.C.S., Albering, H.J., Marx, A., van Maanen, J.M.S., van Agen, B., ten Hoor, F., Swaen, G.M.H. et Mertens, P.L.J.M. (1991) Nitrate contamination of drinking water: evaluation of genotoxic risk in human populations. Environmental Health Perspectives 94, 189-193.

 

Knekt, P., Järvinen, R., Dich, J. et Hakulinen, T. (1999) Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-nitrosocompounds: a follow-up study. International Journal of Cancer 80, 852-856.

 

Knight, T.M., Forman, D., Pirastu, R., Comba, P., Iannarilli, R., Cocco, P.L., Angotzi, G., Ninu, E. et Schierano, S. (1990) Nitrate and nitrite exposure in Italian populations with different gastric cancer rates. International Journal of Epidemiology 19, 510-515.

 

Knobeloch, L. et Anderson, H.A. (2001) Methemoglobinemia: response to Avery. Environmental Health Perspectives 109, (1), A13-A14.

 

Knobeloch, L., Krenz, K., Anderson, H. et Hovell, C. (1993) Methemoglobinemia in an infant – Wisconsin. Morbidity and Mortality Weekly Report 42, 217-219 (erratum: 1993, 42,342).

 

Knobeloch, L., Salna, B., Hogan, A., Postle, J. et Anderson, H. (2000) Blue babies and nitrate-contamined well water. Environmental Health Perspectives 108, 675-678.

 

Knoteck, Z. et Schmidt, P. (1960) Contribution to the mechanism of the occurrence of nitrate alimentary methemoglobinemia in infants II The effect of dried milk. Ceskoslovenska Hygiena 5, 592-599 (en tchèque).

 

Knotek, Z. et Schmidt, P. (1964) Pathogenesis, incidence and possibilities of preventing alimentary nitrate methemoglobinemia in infants. Pediatrics 34, 78-83.

 

Kono, S. et Hirohata, T. (1996) Nutrition and stomach cancer. Cancer Causes and Control 7, 41-55.

 

Kortboyer, J.M., Colbers, E.P.H., Vaessen, H.A.M.G., Groen, K., Zeilmaker, M.J., Slob, W., Speijers, G.J.A. et Meulenbelt, J. (1995) A pilot-study to investigate nitrate and nitrite kinetics in healthy volunteers with normal and artificially increased gastric pH after sodium nitrate ingestion. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite). Bilthoven (Netherlands) 8-10 November 1994. Council of Europe Press, Strasbourg, pp. 269-284.

 

Kosaka, H. et Tyuma, I. (1987) Mechanism of autocatalytic oxidation of oxyhemoglobin by nitrite. Environmental Health Perspectives 78, 147-151.

 

Kosaka, H. Imaizumi, K., Imai, K. et Tyuma, I. (1979) Stoichiometry of the reaction of oxyhemoglobin with nitrite. Biochimica et Biophysica Acta 581, 184-188.

 

Kosaka, H., Wishnok, J.S., Miwa, M., Leaf, C.D. et Tannenbaum, S.R. (1989) Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates. Carcinogenesis 10, 563-566.

 

Koshland, D.E. (1992) The molecule of the year. Science 258, 1861.

 

Kostraba, J.N., Gay, E.C., Rewers, M. et Hamman, R.F. (1992) Nitrate levels in community drinking waters and risk of IDDM. An ecological analysis. Diabetes Care 15, 1505-1508.

 

Krafte-Jacobs, B., Brilli, R., Szabo, C., Denenberg, A., Moore, L. et Salzman, A.L. (1997) Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. Critical Care Medicine 25, 1588-1593.

 

Kross, B.C., Hallberg, G.R., Bruner, D.R., Cherryholmes, K. et Johnson, J.K. (1993) The nitrate contamination of private well water in Iowa. American Journal of Public Health 83, 270-272.

 

Kupferminc, M., Silver, R., Russell, T., Adler, R., Mullen, T. et Caplan, M. (1996) Evaluation of nitric oxide as a mediator of severe preeclampsia. American Journal of Obstetrics and Gynecology 174, 451.

 

Kyrtopoulos, S.A. (1989) N-nitroso compound formation in human gastric juice. Cancer Surveys 8, 423-442.

 

Kyrtopoulos, S.A., Pignatelli, B., Karkanias, G., Golematis, B. et Esteve, J. (1991) Studies in gastric carcinogenesis. V. The effects of ascorbic acid on N-nitroso compound formation in human gastric juice in vivo and in vitro. Carcinogenesis 12, 1371-1376.

 

L et de B (1759) Dictionnaire Portatif de Santé, par Mr L., ancien médecin des armées du Roi et Mr de B., médecin des hôpitaux.

 

Laakso, M., Mutru, O., Isomäki, H. et Koota, K. (1986) Cancer mortality in patients with rheumatoid arthritis. Journal of Rheumatology 13, 522-526.

 

Laegreid, M., Böckman, O.C. et Kaarstad, O. (1999) Agriculture, Fertilizers and the Environment, CAB International, Wallingford, UK, 294 pp.

 

Lamarque, D., Kiss, J., Whittle, B. et Delchier, J-C. (1996) Rôle du monoxyde d’azote dans le maintien de l’intégrité muqueuse et dans la pathologie inflammatoire gastro-intestinale. Gastroentérologie Clinique et Biologique 20, 1085-1098.

 

Landmann, G. (1990) Bilan de 5 années de recherches (1985-1990) dans le cadre du programme DEFORPA. La Santé des Forêts 51-55.

 

Laue, W., Thiemann, M., Scheibler, E. et Wiegand, K.W. (1991) Nitrates and nitrites. In: Elvers, B., Hawkins, S. et Schulz, G. (eds) Ullmann's Encyclopedia of Industrial Chemistry, Fifth Edition, Volume A17, pp. 265-266, 271-272.

 

Law, G., Parslow, R., McKinney, P. et Cartwright, R. (1999) Non-Hodgkin's lymphoma and nitrate in drinking water: a study in Yorkshire, United Kingdom. Journal of Epidemiology and Community Health 53, 383-384.

 

Leach, S.A., Thompson, M. et Hill, M. (1987) Bacterially catalysed N-nitrosation reactions and their relative importance in the human stomach. Carcinogenesis 8, 1907-1912.

 

Leaf, C.D. et Tannenbaum, S.R. (1996) The role of dietary nitrate and nitrite in human cancer. In: Watson, R. et Muftti, S.I. (eds) Nutrition and Cancer Prevention. CRC Press., Boca Raton, Florida, pp. 317-324.

 

Leaf, C.D., Vecchio, A.J., Roe, D.A. et Hotchkiss, J.H. (1987) Influence of ascorbic acid dose on N-nitrosoproline formation in humans. Carcinogenesis 8, 791-795.

 

Leaf, C.D., Wishnok, J.S. et Tannenbaum, S.R. (1990) Nitric oxide: the dark side. In: Moncada, S et Higgs, E.A. (eds) Nitric Oxide from L-Arginine: a Bioregulatory System. Elsevier Science, Amsterdam, pp. 291-299.

 

Lebby, T., Roco, J.J. et Arcinue, E.L. (1993) Infantile methemoglobinemia associated with acute diarrheal illness. American Journal of Emergency Medicine 11, 471-472.

 

Leclerc, H., Vincent, P. et Vandevenne, P. (1991) Nitrates de l’eau de boisson et cancer. Annales de Gastroentérologie et d’Hépatologie 27, 326-332.

 

Lee, K., Greger, J.L., Consaul, J.R., Graham, K.L. et Chinn, B.L. (1986) Nitrate, nitrite balance, and de novo synthesis of nitrate in humans consuming cured meats. American Journal of Clinical Nutrition 44, 188-194.

 

Lefebvre, J.-M. (1976) Les nitrates et nitrites dans les plantes. Annales de la Nutrition et de l’Alimentation 30, 661-665.

 

Lehman, A.J. (1958) Quaterly report to the edition on topics of current interest. Nitrates and nitrites in meat products. Quarterly Bulletin Association of Food and Drug Officials 22, 136-138.

 

Lemery, N. (1733) Dictionnaire Universel des Drogues Simples, Contenant leurs Noms, Origine, Choix, Principes, Vertus, Etimologie; et ce qu’il y a de particulier dans les Animaux, dans les Végétaux et dans les Minéraux. Veuve d’Houry, Paris.

 

Leone, A.M., Francis, P.L., Rhodes, P. et Moncada, S. (1994) A rapid and simple method for the measurement of nitrite and nitrate in plasma by high performance capillary electrophoresis. Biochemical and Biophysical Research Communications 200, 951-957.

 

L’Hirondel, J. (1964) Les régimes prolongés à base de soupe de carottes. Ouest Medical 23, 1159-1162.

 

L’Hirondel, J. (1993a) Le métabolisme des nitrates et des nitrites chez l’homme. Cahiers de Nutrition et de Diététique 28, 341-349.

 

L’Hirondel, J. (1993b) Les méthémoglobinémies du nourrisson. Données nouvelles. Cahiers de Nutrition et de Diététique 28, 35-40.

 

L’Hirondel, J. (1994) Les nitrates de l’alimentation chez l’homme: métabolisme et innocuité. Food nitrates in humans: metabolism and innocuity. Comptes rendus de l’Académie d’Agriculture de France 80, 41-52.

 

L’Hirondel, J. et L’Hirondel, J-L. (1996) Les Nitrates et l’Homme, le mythe de leur toxicité. Editions de l’Institut de l’Environnement, Liffré, France, 142 pp.

 

L’Hirondel, J., Guihard, J., Morel, C., Freymuth, F., Signoret, N. et Signoret, C. (1971) Une cause nouvelle de méthémoglobinémie du nourrisson: la soupe de carottes. Annales de Pédiatrie 18, 625-632.

 

L’Hirondel, J.L  (1998) L’innocuité des nitrates alimentaires. Médecine /Sciences, 14, 636-639.

 

L’Hirondel, J-L. (1999a) Dietary nitrates pose no threat to human health. In: Mooney, L. et Bate, R. (eds.) Environmental Health. Third World Problems – First World Preoccupations. Butterworth-Heinemann, Oxford, UK, pp. 119-128.

 

L’Hirondel, J.L. (1999b) Are dietary nitrates a threat to human health? In: Morris, J et Bate, R. (eds.) Fearing Food: Risk, Health and Environment. Butterworth-Heinemann, Oxford, UK, pp. 38-46.

 

L’Hirondel, J-L. (1999c) Nitrates: une erreur mondiale. Le Quotidien du Médecin 6457, 59.

 

L’hirondel, J.-L. (2000) Les effets bénéfiques des nitrates alimentaires. Implications sanitaires. Fusion 82, 41-45.

 

Li, H., Duncan, C., Townend, J., Killham, K., Smith, L.M., Johnston, P., Dykhuizen, R., Kelly, D., Golden, M., Benjamin, N. et Leifert, C. (1997) Nitrate-reducing bacteria on rat tongues. Applied and Environmental Microbiology 63, 924-930.

 

Licht, W.R. et Deen, W.M. (1988) Theoretical model for predicting rates of nitrosamine and nitrosamide formation in the human stomach. Carcinogenesis 9, 2227-2237.

 

Licht, W.R.., Tannenbaum, S.R. et Deen, W.M. (1988) Use of ascorbic acid to inhibit nitrosation: kinetic and mass transfer considerations for an in vitro system. Carcinogenesis 9, 365-372.

 

Lindquist, B. et Söderhjelm, L. (1975) Nitrate in children food and the risk for methaemoglobinaemia. Läkartidningen 72, 3011-3012 (en suédois).

 

Littré, E. (1886) Dictionnaire de Médecine, de Chirurgie, de Pharmacie, de l’Art Vétérinaire et des Sciences qui s’y Rapportent. 16ème édn. J.-B. Baillière et Fils, Paris, 1876 pp.

 

Lu, G.et Yan-Sheng, G. (1991) Acute nitrate poisoning: a report of 80 cases. American Journal of Emergency Medicine 9, 200-201.

 

Luca, D., Raileanu, L., Luca, V. et Duda, R. (1985) Chromosomal aberrations and micronuclei induced in rat and mouse bone marrow cells by sodium nitrate. Mutation Research 155, 121-125.

 

Luepker, R.V., Pechacek, T.F., Murray, D.M., Johnson, C.A., Hund, F. et Jacobs, D.R. (1981) Saliva thiocyanate: a chemical indicator of cigarette smoking in adolescents. American Journal of Public Health 71, 1320-1324.

 

Luhby, A.L., Glass, G.B.J. et Slobody, L.B. (1954) Studies of the gastric mucoprotein secretion in infants and children. American Journal of Diseases of Children 88,517.

 

Lukens, J.N. (1987) The legacy of well-water methemoglobinemia. Journal of the American Medical Association 257, 2793-2795.

 

Lundberg, J.O.N., Weitzberg, E., Lundberg, J.M. et Alving, K. (1994) Intragastric nitric oxide production in humans: measurements in expelled air. Gut 35, 1543-1546.

 

Lundberg, J.O.N., Carlsson, S., Engstrand, L., Morcos, E., Wiklund, N.P. et Weitzberg, E. (1997) Urinary nitrite: more than a marker of infection. Urology 50, 189-191.

 

Lutynski, R., Steczek-Wojdyla, M., Wojdyla, Z. et Kroch, S. (1996) The concentrations of nitrates and nitrites in food products and environment and the occurrence of acute toxic methemoglobinemias. Przeglad Lekarski 53, 351-355.

 

Maekawa, A., Ogiu, T., Onodera, H., Furuta, K., Matsuoka, C., Ohno, Y. et Odashima, S. (1982) Carcinogenicity studies of sodium nitrite and sodium nitrate in F-344 rats. Food and Chemical Toxicology 20, 25-33.

 

MAFF (1987) Nitrate, Nitrite and N-nitroso Compounds in Food. The working party on nitrate and nitrite compounds in food. Food Surveillance Paper no. 20, Ministry of Agriculture, Fisheries and Food, HMSO, London.

 

Magee, P.N. et Barnes, J.M. (1956) The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. British Journal of Cancer 10, 114-122.

 

Malberg, J.W., Savage, E.P. et Osteryoung, J. (1978) Nitrates in drinking water and the early onset of hypertension. Environmental Pollution 15, 155-160.

 

Maleysson, F. et Michels, S. (1993) Nitrates dans les légumes. Les progrès se font attendre. Que Choisir 297, 35-37.

 

Manley, C.H. (1945) A fatal case of sodium nitrite poisoning. Analyst 70, 50.

 

Mansouri, A. et Lurie, A.A. (1993) Concise review: methemoglobinemia. American Journal of Hematology 42, 7-12.

 

Marco, A., Quilchano, C. et Blaustein, A.R. (1999) Sensitivity to nitrate and nitrite in pond-breeding amphibians from the Pacific Northwest, USA. Environmental Toxicology and Chemistry 18, 2836-2839.

 

Maringe, E. (1987) Environnement et incidence des cancers digestifs. Etude dans le département de la Côte-d’Or (1976-1984). Thèse de Médecine, Université de Dijon, France.

 

Mariotti, A. (1998) Nitrate: un polluant de longue durée. Pour la Science 249, 60-65

 

Markowitz, K. et Kim S. (1990) Hypersensitive teeth. Experimental studies of dentinal desensitizing agents. Dental Clinics of North America 34, 491-501.

 

Markowitz, K et Kim, S (1992) The role of selected cations in the desensitization of intradental nerves. Proceedings of the Finnish Dental Society 88 (Suppl I), 39-54.

 

Marletta, M.A., Tayeh, M.A. et Hevel, J.M. (1990) Unraveling the biological significance of nitric oxide. BioFactors 2, 219-225.

 

Marriott, W.M., Hartmann, A.F. et Senn, M.J.E. (1933) Observations on the nature and treatment of diarrhea and the associated systemic disturbances. Journal of Pediatrics 3, 181-191.

 

Matsumoto, A., Hirata, Y., Kakoki, M., Nagata, D., Momomura, S., Sugimoto, T., Tagawa, H. et Omata, M. (1999) Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure. Clinical Science 96, 67-74.

 

May, R.B. (1985) An infant with sepsis and methemoglobinemia. The Journal of Emergency Medicine 3; 261-264.

 

Mayerhofer, E. (1913) Der Harn des Säuglings. Ergebnisse der inneren Medizin und Kinderheilkunde 12, 553-618 (page 579).

 

McKee, J.E. et Wolf, H.W. (1963) Water Quality Criteria, 2nd edn. State Water Quality Control Board, Sacramento, California, 548 pp.

 

McKenna, P. (1998) Report on the Commission Reports on the Implementation of Council Directive 91/676/EEC. Committee on the Environment, Public Health and Consumer Protection (A4-024/98), EC, Brussels.

 

McKinney, P.A., Parslow, R. et Bodansky, H.J. (1999) Nitrate exposure and childhood diabetes. In: Wilson, W.S., Ball, A.S. et Hinton, R.H. (eds) Managing Risks of Nitrates to Humans and the Environment, Royal Society of Chemistry, Cambridge, UK, pp. 327-339.

 

McKnight, G.M., Smith, L.M., Drummond, R.S., Duncan, C.W., Golden, M. et Benjamin, N. (1996) Chemical synthesis of nitric oxide in the stomach from dietary nitrate in man. Gastroenterology 110, 4, A 1099.

 

McKnight, G.M., Smith, L.M., Drummond, R.S., Duncan, C.W., Golden, M. et Benjamin, N. (1997a) Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. Gut 40, 211-214.

 

McKnight, G.M., Smith, L.M., Golden, M. et Benjamin, N. (1997b) Dietary nitrate inhibits human platelet aggregation. Gastroenterology 112, (4 suppl) A 893.

 

McKnight, G.M., Duncan, C.W., Leifert, C. et Golden, M.H. (1999) Dietary nitrate in man: friend or foe? British Journal of Nutrition 81, 349-358.

 

Melichar, B., Bures, J., Komarkova, O., Rejchrt, S., Fixa, B. et Karlicek, R. (1995) Increased gastric juice nitrate is associated with biliary reflux and Helicobacter pylori infection. American Journal of Gastroenterology 90, 1190-1191.

 

Meredith, T.J., Jacobsen, D., Haines, J.A., Berger, J.-C et Van Heijst A.N.P. (1993) Antidotes for Poisoning by Cyanide: International Program on Chemical Safety/Commission of the European Communities. Cambridge University Press.

 

Meunier, P., Minaire, Y. et Lambert, R. (1988) La Digestion, 2ème édn. Simep, Paris, pp.120-133.

 

Miller, C.T. (1984) Unscheduled DNA synthesis in human leukocytes after a fish (amine source) meal with or without salad (nitrite source). In: O’Neill, I.K., von Borstel, R.C., Miller, C.T., Long, J. et Bartsch, H. (eds) N-nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer. IARC Scientific Publications no. 57, Lyon, France, pp. 609-613.

 

Miller, R.A. (1941) Observations on the gastric acidity during the first month of life. Archives of Disease in Childhood 16, 22-30.

 

Mirvish, S.S. (1995) Role of N-nitroso compounds (NOC) and N-nitrosation in the etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Letters 93, 17-48.

 

Mirvish, S.S., Patil, K., Ghadirian, P. et Kommineni, V.R.C. (1975) Disappearance of nitrite from the rat stomach: contribution of emptying and other factors. Journal of the National Cancer Institute 54, 869-875.

 

Mitchell, H.H., Shonle, H.A. et Grindley, H.S. (1916) The origin of the nitrates in the urine. Journal of Biological Chemistry 24, 461-490.

 

Mitsui, T. et Kondo, T. (1999) Vegetables, high nitrate foods, increased breath nitrous oxide. Digestive Diseases and Science 44, 1216-1219.

 

Miwa, M., Stuehr, D.J., Marletta, M.A., Wishnok, J.S. et Tannenbaum, S.R. (1987) Nitrosation of amines by stimulated macrophages. Carcinogenesis 8, 955-958.

 

Moeschlin, S. (1972) Klinik und Therapie der Vergiftungen 2 Neubearbeitete Auflage. Georg Thieme Verlag, Stuttgart, pp. 145-147.

 

Möhler, K. et Zeltner, I. (1981) Das nitrat/nitritproblem in der menschliden nahrung. II. Vorkommen von nitrat, nitrit und thiocyanat im menschliden speichel. Zeitschrift für Lebensmittel-Untersuchung und Forschung 173, 40-46.

 

Mohri, T. (1993) Nitrates and nitrites. In: Encyclopaedia of Food Science, Technology and Nutrition. Academic Press, London, pp. 3240-3244.

 

Molina, J.A., Jimenez-Jimenez, F.J., Navarro, J.A., Ruiz, E., Arenas, J., Cabrera-Valdivia, F., Vazquez, A., Fernandez-Calle, P., Ayuso-Peralta, L., Rabasa, M. et Bermejo, F. (1994) Plasma levels of nitrates in patients with Parkinson’s disease. Journal of the Neurological Sciences 127, 87-89.

 

Monafo, W.W., Tandon, S.N., Ayvazian, V.H. Tuchschmidt, B.S., Skimmer, A.M. et Deitz, F. (1976) Cerium nitrate: a new topical antiseptic for extensive burns. Surgery 80, 465-473.

 

Moncada, S., Higgs, A. et Furchgott, R. (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacological Reviews 49, 137-142.

 

Morales Suarez-Varela, M., Llopis-Gonzalez, A., Tejerizo-Perez, M.L. et Ferragud J.F. (1993) Concentration of nitrates in drinking water and its relationship with bladder cancer. Journal of Environmental Pathology, Toxicology and Oncology 12, 229-236.

 

Morales-Suarez-Varela, M.M., Llopis-Gonzalez, A. et Tejerizo-Perez, M.L. (1995) Impact of nitrates in drinking water on cancer mortality in Valencia, Spain. European Journal of Epidemiology11,15-21.

 

Moriyama, A., Masumoto, A., Nanri, H., Tabaru, A., Unoki, H., Imoto, I., Ikeda, M. et Otsuki, M. (1997) High plasma concentrations of nitrite/nitrate in patients with hepatocellular carcinoma. American Journal of Gastroenterology 92, 1520-1523.

 

Morlon, P. (1998) Vieilles lunes? Les normes pour les bâtiments d’élevage ont cent cinquante ans, le code de bonnes pratiques agricoles en a cent …- Courrier de l’Environnement de l’INRA 33, 45-60.

 

Morton, W.E. (1971a) Hypertension and drinking water constituents in Colorado. American Journal of Public Health 61, 1371-1378.

 

Morton, W.E. (1971b) Hypertension and drinking water. A pilot statewide ecological study in Colorado. Journal of Chronic Diseases 23, 537-545.

 

Moshage, H., Kok, B., Huizenga, J.R. et Jansen, P.L.M. (1995) Nitrite and nitrate determinations in plasma: a critical evaluation. Clinical Chemistry 41, 892-896.

 

Mosier, A., Kroeze, C., Nevinson, C., Oenema, O., Seitzinger, S. et Van Cleemput, O. (1998) Closing the global N2O budget: nitrous oxide emissions through the agricultural nitrogen cycle. Nutrient Cycling in Agroecosystems 52, 225-248.

 

Mowat, C., Carswell, A., Wirz, A. et McColl, K.E.L. (1999) Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 116, 813-822.

 

Moyer, C.A., Brentano, L., Gravens, D.L, Margraf, H.W. et Monafo, W.M. (1965) Treatment of large human burns with 0,5 % silver nitrate solution. Archives of Surgery 90, 812-867.

 

Muijsers, R.B.R., Folkerts, G., Henricks, P.A.J., Sadeghi-Hashjin, G. et Nijkamp, F.P. (1997) Peroxynitrite: a two-faced metabolite of nitric oxide. Life Sciences 60, 1833-1845.

 

Murray, K.F. et Christie, D.L. (1993) Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea. The Journal of Pediatrics 122, 90-92.

 

Myatt, L., Brewer, A. et Prada, J. (1992) Nitric oxide production in normotensive pregnancy: measurement of urinary nitrate. 39th Annual Meeting, Society for Gynecologic Investigation, San Antonio, Texas, p. 155.

 

Nagata, K., Yu, H., Nishikawa, M. Kashiba, M., Nakamura, A., Sato, E.F., Tamura, T. et Inoue, M. (1998) Helicobacter pylori generates superoxide radicals and modulates nitric oxide metabolism. Journal of Biological Chemistry 273, 14071-14073.

 

Nakashima, Y., Toyokawa, T., Tanaka, S., Yamashita, K., Yashiro, A., Tasaki, H. et Kuroiwa, A. (1996) Simvastatin increases plasma NO2- and NO3- levels in patients with hypercholesterolemia. Atherosclerosis 127, 43-47.

 

Nanno, H., Sagawa, N., Itoh, H., Matsumoto, T., Terakawa, K., Mise, H., Okumura, K.K., Mori, T., Itoh, H. et Nakao, K. (1998) Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress. Prenatal and Neonatal Medicine 3, 222-226.

 

NAS (1981) The Health Effects of Nitrate, Nitrite and N-nitroso compounds. National Academy of Sciences, National Academy Press, Washington, D.C, 537 pp.

 

Neal, K.R., Brij, S.O., Slack, R.C.B., Hawken, C.J. et Logan, R.F.A. (1994) Recent treatment with H2 antagonists and antibiotics and gastric surgery as risk factors for salmonella infection. British Medical Journal 308, 176.

 

Neilly, I.J., Copland, M., Haj, M., Adey, G., Benjamin, N. et Bennett, B. (1995) Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia. British Journal of Haematology 89, 199-202.

 

Ness, A.R. et Powles, J.W. (1997) Fruit and vegetables, and cardiovascular disease: a review. International Journal of Epidemiology 26, 1-13.

 

Nobunaga, T., Tokugawa, Y., Hashimoto, K., Kimura, T., Matsuzaki, N., Nitta, Y., Fujita, T., Kidoguchi, K., Azuma, C. et Saji, F. (1996) Plasma nitric oxide levels in pregnant patients with preeclampsia and essential hypertension. Gynecologic and Obstetric Investigation 41, 181-193.

 

Nousbaum, J.B. (1989) Nitrates et cancers gastriques. Etude dans le département du Finistère. Thèse de doctorat en médecine. Faculté de médecine de Brest. Université de Bretagne Occidentale, France, 166 pp.

 

NRC (1972) Hazards of nitrate, nitrite, and nitrosamines to man and livestock. In: National Research Council, Committee on Nitrate Accumulation. Accumulation of Nitrate. National Academy of Sciences, Washington, DC, pp. 46-75.

 

NRC (1995) National Research Council. Subcommittee on Nitrate and Nitrite in Drinking Water. Nitrate and Nitrite in Drinking Water. National Academy Press, Washington, DC, 63 pp.

 

OECD (1986) Water Pollution by Fertilizers and Pesticides. Organisation for Economic Cooperation and Development, Paris, 144 pp.

 

Ogilvie, A.C., Hack, C.E., Wagstaff, J., van Mierlo, G.J., Eerenberg, A.J.M., Thomsen, L.L., Hoekman, K. et Rankin, E.M. (1996) IL-1ß does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer. Journal of Immunology 156, 389-394.

 

Ogle, C.W. et Qiu, B.S. (1993) Nitric oxide inhibition intensifies cold-restraint induced gastric ulcers in rats. Experientia 49, 304-307.

 

Ohshima, H. et Bartsch, H. (1981) Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine. Cancer Research 41, 3658-3662.

 

Ohshima, H. et Bartsch, H. (1988) Urinary N-nitrosamino acids as an index of exposure to N-nitroso compounds. In: Bartsch, H., Hemminki, K. et O'Neill, I.K. (eds) Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention. IARC Scientific Publications 89, Lyon, pp. 83-91.

 

Okutomi, T., Nomoto, K., Nakamura, K. et Goto, F. (1997) Nitric oxide metabolite in pregnant women before and after delivery. Acta Obstetrica et Gynecologica Scandinavica 76, 222-226.

 

ONC (1994) Office National de la Chasse. Tableaux de chasse: cerf, chevreuil, sanglier. Saison 1993-1994. Supplément Bulletin Mensuel no. 192, Paris.

 

Orchardson, R. et Gillam, D.G. (2000) The efficacy of potassium salts as agents for treating dentin hypersensitivity. Journal of Orofacial Pain 14, 9-19.

 

Örem, A., Vanizor, B., Cimsit, G., Kiran, E., Deger, O. et Malkoç, M. (1999) Decreased nitric oxide production in patients with Behçet’s disease. Dermatology 198, 33-36.

 

Palli, D., Bianchi, S., Decarli, A., Cipriani, F., Avellini, C., Cocco, P., Falcini, F., Puntoni, R., Russo, A., Vindigni, C., Fraumeni, J.F., Blot, W.J. et Buiatti, E. (1992) A case-control study of cancers of the gastric cardia in Italy. British Journal of Cancer 65, 263-266.

 

Parslow, R.C., McKinney, P.A., Law, G.R., Staines, A., Williams, R. et Bodansky, H.J. (1997) Incidence of childhood diabetes mellitus in Yorkshire, Northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia 40, 550-556.

 

Parsonnet, J., Vandersteen, D., Goates, J., Sibley, R.K., Pritikin, J. et Chang, Y. (1991) Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas. Journal of the National Cancer Institute 83, 640-643.

 

Parsons, M.L. (1978) Is the nitrate drinking water standard unnecessarily low?  Current research indicates that it is. American Journal of Medical Technology 44, 952-954.

 

Pascal, P. et Dubrisay, R. (1956) Le cycle de l’azote dans la nature. In: Nouveau Traité de Chimie Minérale, vol. 10, Azote, Phosphore. Masson, Paris, pp. 57-59.

 

Pathak, N., Sawhney, H., Vasishta, K. et Majumdar, S. (1999) Estimation of oxidative products of nitric oxide (nitrates, nitrites) in preeclampsia. Australian and New Zealand Journal of Obstetrics and Gynaecology 39, 484-487.

 

Pavia, A.T., Shipman, L.D., Wells, J.G., Puhr, N.D., Smith, J.D., MacKinley, T.W. et Tauxe, R.V. (1990) Epidemiological evidence that prior antimicrobial exposure decreases resistance to infection by antimicrobial-sensitive Salmonella. The Journal of Infectious Diseases 161, 255-260.

 

Pennisi, E. (2000) Integrating the many aspects of biology. Science 287, 419-421.

 

 

 


Petukhov, N.I. et Ivanov, A.V. (1970) Investigation of certain psychophysiological reactions in children with water nitrate methemoglobinemia. Hygiene and Sanitation (Gigiena i sanitaria) 35, 26-28 (en russe).

 

Pignatelli, B., Malaveille, C., Chen, C., Hautefeuille, A., Thuillier, P., Munoz, N., Moulinier, B., Berger, F., De Montclos, H., Ohshima, H., Lambert, R. et Bartsch, H. (1991) N-nitroso compounds, genotoxins and their precursors in gastric juice from humans with and without precancerous lesions of the stomach. In: O’Neill, I.K., Chen, J. et Bartsch, H. (eds). Relevance to Human Cancer of N-nitroso Compounds, Tobacco Smoke and Mycotoxins. IARC Scientific Publications 105, Lyon, France, pp 172-177.

 

Pignatelli, B., Malaveille, C., Rogatko, A., Hautefeuille, A., Thuillier, P., Munoz, N., Moulinier, B., Berger, F., De Montclos, H., Lambert, R., Correa, P., Ruiz, B., Sobala, G.M., Schorah, C.J., Axon, A.T.R. et Bartsch, H. (1993) Mutagens, N-nitroso compounds and their precursors in gastric juice from patients with and without precancerous lesions of the stomach. European Journal of Cancer 29A, 2031-2039.

 

Pique, J.M., Whittle, B.J.R. et Esplugues, J.V. (1989) The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation. European Journal of Pharmacology 174, 293-296.

 

Pluge, W. (1986) The implementation into German Law of EC Directive 80/778 of 15th July 1980 concerning the quality of water for human consumption. Seminar on EEC Directive 80/778 Relating to the Quality of Water Intended for Human Consumption, Como, Italy.

 

Pobel, D., Riboli, E., Cornée, J., Hémon, B. et Guyader, M. (1995) Nitrosamine, nitrate and nitrite in relation to gastric cancer: a case-control study in Marseille, France. European Journal of Epidemiology 11, 67-73.

 

Poch, M. (1987) Mögliche zusammenhänge zwischen der nitratbelastung des trinkwassers und neoplastischen erkrankungen des Magen-Darm-Kanals. Zeitschrift für die Gesamte Hygiene und ihre Grenzgebiete 33, 528-529.

 

Pocock, S.J., Shaper, A.G., Cook, D.G., Packham, R.F., Lacey, R.F., Powell, P. et Russell, P.F. (1980) British Regional Heart Study: geographic variations in cardiovascular mortality, and the role of water quality. British Medical Journal 280, 1243-1249.

 

 

Polenske, E. (1891) Über den Verlust, welchen das Rinkfleisch und Nahrwert durch das Pokein erleidet, sowie über die Veränderungen salpeterhaltiger Pokellaken. Arbeiten aus dem Kaiserlichen Gesundheitzamte 7, 471.

 

Pollack, E.S. et Pollack, C.V. (1994) Incidence of subclinical methemoglobinemia in infants with diarrhea. Annals of Emergency Medicine 24, 652-656.

 

Preiser, J.C., De Backer, D., Debelle, F., Vray, B. et Vincent, J.L. (1998) The metabolic fate of long-term inhaled nitric oxide. Journal of Critical Care 13, 97-103

 

Preussmann, R. et Wiessler, M. (1987) The enigma of the organ-specificity of carcinogenic nitrosamines. Topical Information from Pergamon Software 8, 185-189.

 

Pryor, W.A. et Squadrito, G.L. (1995) The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. American Journal of Physiology 28 (Lung Cellular and Molecular Physiology 12) L699-L722.

 

Puente, X., Villares, R.., Carral, E. et Carballeira, A. (1996) Macroalgal proliferation (Ulva “bloom”) along a pattern of eutrophication in coastal areas of Galicia (NW Spain). Actes du 1er Colloque Interceltique d’Hydrologie et de Gestion des Eaux. Bretagne 96. Rennes, 8-11 Juillet. Editions INSA, pp.81-82.

 

Rademacher, J.J., Young, T.B. et Kanarek, M.S. (1992) Gastric cancer mortality and nitrate levels in Wisconsin drinking water. Archives of Environmental Health 47, 292-294.

 

Rafnsson, V. et Gunnarsdottir, H. (1990) Mortality study of fertiliser manufacturers in Iceland. British Journal of Industrial Medicine 47, 721-725.

 

Ranta, V., Viinikka, L., Halmesmäki, E. et Ylikorkala, O. (1999) Nitric oxide production with preeclampsia. Obstetrics and Gynecology 93, 442-445.

 

Rao, G.S. (1980) Salivary nitrite and carcinogenic nitrosamine formation - report of research. Dental Abstracts 25, 228-231.

 

Rathbone, B.J., Johnson, A.W., Wyatt, J.I., Kelleher, J., Heatley, R.V. et Losowsky, M.S. (1989) Ascorbic acid: a factor concentrated in human gastric juice. Clinical Science 76, 237-241.

 

Rawls, R. (1998) Not all NO notables get Nobel nod. Chemical and Engineering News 76, October 26, 48.

 

Reed, M.D. (1996) Principles of drug therapy. In: Behrman, R.E., Kliegman, R.M. et Arvin, A.M. (eds) Nelson Textbook of Pediatrics. 15th edn W.B. Saunders Company, Philadelphia, pp. 290-298.

 

Rees, D.C., Cervi, P., Grimwade, D., O’Driscoll, A., Hamilton, M., Parker, N.E. et Porter, J.B. (1995a) The metabolites of nitric oxide in sickle-cell disease. British Journal of Haematology 91, 834-837.

 

Rees, D.C., Satsangi, J., Cornelissen, P.L., Travis, S.P., White, J. et Jewell, D.P. (1995b) Are serum concentrations of nitric oxide metabolites useful for predicting the clinical outcome of severe ulcerative colitis?. European Journal of Gastroenterology and Hepatology 7, 227-230.

 

Ringqvist, A., Leppert, J., Myrdal, U., Ahlner, J., Ringqvist, I. et Wennmalm, A. (1997) Plasma nitric oxide metabolite in women with primary Raynaud’s phenomenon and in healthy subjects. Clinical Physiology 17, 269-277.

 

Risch, H.A., Jain, M., Choi, N.W., Fodor, J.G., Pfeiffer, C.J., Howe, G.R., Harrison, L.W., Craib, K.J.P. et Miller, A.B. (1985) Dietary factors and the incidence of cancer of the stomach. American Journal of Epidemiology 122, 947-959.

 

Robbins, R.A. et Rennard, S.I. (1997) Biology of airway epithelial cells. In: Crystal, R.G., West, J.B., Weibel, E.R. et Barnes, P.J. (eds) The Lung. Scientific Foundations, Vol. 1. Lippincott-Raven, Philadelphia, pp. 445-457.

 

Rogers, M.A.M., Vaughan, T.L., Davis, S. et Thomas, D.B. (1995) Consumption of nitrate, nitrite and nitrosodimethylamine and the risk of upper aerodigestive tract cancer. Cancer Epidemiology, Biomarkers and Prevention 4, 29-36.

 

Rojas, A. (1992) No increase in chromosome aberrations in lymphocytes from workers exposed to nitrogen fertilisers. Mutation Research 281, 133-135.

 

Rosenfield, A.B. et Huston, R. (1950) Infant methemoglobinemia in Minnesota due to nitrates in well water. Minnesota Medicine 33, 787-796.

 

Rosenkranz, H.S. (1979) A synergistic effect between cerium nitrate and silver sulphadiazine. Burns 5, 278-281.

 

Rosselli, M., Imthurn, B., Macas, E., Keller, P.J. et Dubey, R.K. (1994) Circulating nitrite/nitrate levels increase with follicular development: indirect evidence for estradiol mediated NO release. Biochemical and Biophysical Research Communications 202, 1543-1552.

 

Rosselli, M., Imthurn, B., Keller, P.J., Jackson, E.K. et Dubey, R.K. (1995) Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 ß–estradiol and norethisterone acetate. A two-year follow-up study. Hypertension 25 (part 2), 848-853.

 

Rouzade, M.L., Anton, P., Fioramonti, J., Garcia-Villar, R. Theodorou, V. et Bueno, L. (1999) Reduction of the nociceptive response to gastric distension by nitrate ingestion in rats. Alimentary Pharmacology and Therapeutics 13, 1235-1241.

 

Sagnella, G.A., Markandu, N.D., Onipinla, A.K., Chelliah, R., Singer, D.R.J. et MacGregor, G.A. (1997) Plasma and urinary nitrate in essential hypertension. Journal of Human Hypertension 11, 587-588.

 

Sakaguchi, A.A., Miura, S., Takeuchi, T., Hokari, R., Mizumori, M., Yoshida, H., Higuchi, H., Mori, M., Kimura, H., Suzuki, H. et Ishii H. (1999) Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter pylori gastric ulcer. Free Radical Biology and Medicine 27, 781-789.

 

Sakinis, A. et Wennmalm, A. (1998) Estimation of total rate of formation of nitric oxide in the rat. Biochemical Journal 330, 527-532.

 

Sakinis, A., Jungersten, L. et Wennmalm, A. (1999) An 18oxygen inhalation method for determination of total body formation of nitric oxide in humans. Clinical Physiology 19, 504-509.

 

Salas-Auvert, R., Colmenarez, J. de Ledo, H., Colina, M., Gutierrez, E., Bravo, A., Soto, L. et Azuero, S. (1995) Determination of anions in human and animal tear fluid and blood serum by ion chromatography. Journal of Chromatography A 706, 183-189.

 

Sanz Anquela, J.M., Munoz Gonzalez, M.L., Ruiz Liso, J.M., Rodriguez Manzanilla, L. et Alfaro Torres, J. (1989) Correlación del riesgo de cancer gastrico en la provincia de Soria con el contenido de nitratos en las aguas de bebida. Revista Española de las Enfermedades del Aparato Digestivo 75, 561-565.

 

Sasaki, T. et Matano, K. (1979) Formation of nitrite from nitrate at the dorsum linguae. Journal of the Food Hygienic Society of Japan 20, 363-369.

 

Satoi, S., Kamiyama, Y., Kitade, H., Kwon, A.-H., Yoshida, H., Nakamura, N., Takai, S., Uetsuji, S., Okuda, K., Hara, K. et Takahashi, H. (1998) Prolonged decreases in plasma nitrate levels at early postoperative phase after hepato-pancreato-biliary surgery. Journal of Laboratory and Clinical Medicine 131, 236-242.

 

Sattelmacher, P.G. (1962)  Methämoglobinämie durch Nitrate im Trinkwasser. Schriftenreihe des Vereins für Wasser-, Boden- und Lunfthygiene no. 20. Gustav Fisher Verlag, Stuttgart, 35 pp.

 

Saul, R.L. et Archer, M.C. (1984) Oxidation of ammonia and hydroxylamine to nitrate in the rat and in vitro. Carcinogenesis 5, 77-81.

 

Saul, R.L., Kabir, S.H., Cohen, Z., Bruce, W.R. et Archer, M.C. (1981) Reevaluation of nitrate and nitrite levels in the human intestine. Cancer Research 41, 2280-2283.

 

Schönbein, C.F. (1862) Über das Vorkommen des Ammoniaknitrits in thierischen Flüssigkeiten. Chemische Zentralblatt II, 639.

 

Schuddeboom, L.J. (1995) A survey of the exposure to nitrate and nitrite in foods (including drinking water). In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite). Bilthoven (Netherlands)  8-10 November 1994. Council of Europe Press, Strasbourg, pp. 41-74.

 

Schultz, D.S., Deen, W.M., Karel, S.F., Wagner, D.A. et Tannenbaum, S.R. (1985) Pharmacocinetics of nitrate in humans: role of gastrointestinal absorption and metabolism. Carcinogenesis 6, 847-852.

 

Schulze, W. von et Scheibe, E. (1948) Eine Massenvergiftung mit Natriumnitrit. Klinische Beobachtungen und gerichtsmedizinische Befunde. Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 3, 580-589.

 

Schuytema, G.S. et Nebeker, A.V. (1999) Comparative toxicity of ammonium and nitrate compounds to Pacific treefrog and African clawed frog tadpoles. Environmental Toxicology and Chemistry 18, 2251-2257.

 

Seeler, R.A. (1983) Methemoglobinemia in infants with enteritis. The Journal of Pediatrics 102, 162.

 

Selenka, F. (1983) Nitrat im speichel, serum und harn des menschen nach genuss von speisen mit unterschiedlicher Verdaulichkeit. In: Preussmann, R.. (ed.) Das Nitrosamin-Problem. Verlag Chemie, Weinheim, pp. 145-154.

 

Seligman, S.P., Buyon, J.P., Clancy R.M., Young, B.K. et Abramson, S.B. (1994) The role of nitric oxide in the pathogenesis of preeclampsia. American Journal of Obstetrics and Gynecology 171, 944-948.

 

Sharma, B.K., Santana, I.A., Wood, E.C., Walt, R.P., Pereira, M., Noone, P., Smith, P.L.R., Walters, C.L. et Pounder, R.E. (1984) Intragastric bacterial activity and nitrosation before, during and after treatment with omeprazole. British Medical Journal 289, 717-719.

 

Shen, W., Zhang, X., Zhao, G., Wolin, M.S., Sessa, W. et Hintze, T.H. (1995) Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise. Medicine and Science in Sports and Exercise 27, 1125-1134.

 

Shephard, S.E., Schlatter, Ch. et Lutz, W.K. (1987) Assessment of the risk of formation of carcinogenic N-nitroso compounds from dietary precursors in the stomach. Food and Chemical Toxicology 25, 91-108.

 

Shi, Y., Li, H.Q., Shen, C.-K., Wang, J.-H., Qin, S.-W., Liu, R. and Pan, J (1993) Plasma nitric oxide levels in newborn infants with sepsis. Journal of Pediatrics 123, 435-438.

 

Shiotani, A., Yanaoka, K., Iguchi, M., Saika, A., Itoh, H. et Nishioka, S. (1999) Helicobacter pylori infection reduces intraluminal nitric oxide in humans. Journal of Gastroenterology 34, 668-674.

 

Shuval, H.I. et Gruener, N. (1972) Epidemiological and toxicological aspects of nitrates and nitrites in the environment. American Journal of Public Health 62, 1045-1052.

 

Shuval, H.I. et Gruener, N. (1977) Health Effects of Nitrates in Water. Report EPA-600/1-77-030 US. Environmental Protection Agency, Cincinnati, Ohio, USA.

 

Sierra, M., Gonzalez, A., Gomez-Alamillo, C., Monreal, I., Huarte, E., Gil, A., Sanchez-Casajus, A. et Diez, J. (1998) Decreased excretion of nitrate and nitrite in essential hypertensives with renal vasoconstriction. Kidney International 54 (Suppl. 68), S-10-S-13.

 

Signoret, N. (1970) Méthémoglobinémies par la soupe de carottes. Thèse de doctorat en Médecine. Faculté de médecine de Caen, France.

 

Silva Mendez, L.S., Allaker, R.P., Hardie, J.M. et Benjamin, N. (1999) Antimicrobial effect of acidified nitrite on cariogenic bacteria. Oral Microbiology and Immunology 14, 391-392.

 

Simon, C. (1966) L’intoxication par les nitrites après ingestion d’épinards (une forme de méthémoglobinémie). Archives Françaises de Pédiatrie 23, 231-238.

 

Simon, C., Manzke, H., Kay, H. et Mrowetz, G. (1964) Über vorkommen, pathogenese und möglichkeiten zur prophylaxe der durch nitrit verursachten methämoglobinämie. Zeitschrift für Kinderheilkunde 91, 124-138.

 

Skrivan, J. (1971) Methemoglobinemia in pregnancy (clinical and experimental study). Acta Universitatis Carolinae. Medica 17, 123-161.

 

Smarason, A.K., Allman, K.G., Young, D. et Redman, C.W.G. (1997) Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre-eclampsia. British Journal of Obstetrics and Gynaecology 104, 538-543.

 

Smil, V. (1997) Engrais et démographie. Pour la Science 239, 86-91.

 

Sobala, G.M., Schorah, C.J., Sanderson, M., Dixon, M.F., Tompkins, D.S., Godwin, P. et Axon, T.R..(1989) Ascorbic acid in the human stomach. Gastroenterology 97, 357-363.

 

Sobala, G.M., Pignatelli, B., Schorah, C.J., Bartsch, H., Sanderson, M., Dixon, M.F., Shires, S., King, R.F.G. et Axon, A.T.R. (1991) Levels of nitrite, nitrate, N-nitroso compounds, ascorbic acid and total bile acids in gastric juice of patients with and without precancerous conditions of the stomach. Carcinogenesis 12, 193-198.

 

Solignac, M. (2001) Gestion des risques santé et environnement: le cas des nitrates. Presse Médicale 30, 172-174.

 

Solon, M. (1843) Relaté dans l'article 2719. Journal de Médecine et de Chirurgie Pratiques, à l’Usage des Médecins Praticiens, 14,558.

 

Sondheimer, J.M., Clark, D.A. et Gervaise, E.P. (1985) Continuous gastric pH measurement in young and older healthy preterm infants receiving formula and clear liquid feedings. Journal of Pediatric Gastroenterology and Nutrition 4, 352-355.

 

Speijers, G.J.A. (1995) Different approaches of establishing safe levels for nitrate and nitrite. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite). Bilthoven (Netherlands), 8-10 November 1994. Council of Europe Press, Strasbourg, pp. 287-298.

 

Spiegelhalder, B. (1995) Influence of dietary nitrate on oral nitrite production: relevance to in vivo formation of nitrosamines. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite). Bilthoven (Netherlands), 8-10 November 1994. Council of Europe Press, Strasbourg, pp. 125-136.

 

Spiegelhalder, B., Eisenbrand, G. et Preussmann, R. (1976) Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food and Cosmetics Toxicology 14, 545-548.

 

Sporer K.A. et Mayer, A.P. (1991) Saltpeter ingestion. American Journal of Emergency Medicine 9, 164-165.

 

Steindorf, K., Schlehofer, B., Becher, H., Hornig, G. et Wahrendorf, J. (1994) Nitrate in drinking water. A case-control study on primary brain tumours with an embedded drinking water survey in Germany. International Journal of Epidemiology 23, 451-457.

 

Steinmetz, K.A. et Potter, J.D. (1991a) Vegetables, fruit, and cancer. I. Epidemiology. Cancer, Causes and Control 2, 325-357.

 

Steinmetz, K.A. et Potter, J.D. (1991b) Vegetables, fruit, and cancer. II. Mechanisms. Cancer, Causes and Control 2, 427-442.

 

Stephany, R.W. et Schuller, P.L. (1980) Daily dietary intakes of nitrate, nitrite and volatile N-nitrosamines in the Netherlands using the duplicate portion sampling technique. Oncology 37, 203-210.

 

Sternberg, J.M. (1996) Elevated serum nitrate in Trypanosoma brucei “rhodesiense” infections: evidence for inducible nitric oxide synthesis in trypanosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 395.

 

Stichtenoth, D.O. et Frölich, J.C. (1998) Nitric oxide and inflammatory joint diseases. British Journal of Rheumatology 37, 246-257.

 

Stichtenoth, D.O., Fauler, J., Zeidler, H. et Frölich, J.C. (1995a) Urinary nitrate excretion is increased in patients with rheumatoid arthritis and reduced by prednisolone. Annals of Rheumatic Diseases 54, 820-824.

 

Stichtenoth, D.O., Wollenhaupt, J., Andersone, D., Zeidlek, H. et Frölich, J.C. (1995b) Elevated serum nitrate concentration in active spondyloarthropathies. British Journal of Rheumatology 34, 616-619.

 

Stoiser, B., Maca, T., Thalhammer, F., Hollenstein, U., El Menyawi, I. et Burgmann, H. (1999) Serum nitrate concentrations in patients with peripheral arterial occlusive disease. Vasa 28, 181-184.

 

Stokvis, B.J. (1902) Zur casuistic der autotoxischen enterogenen cyanosen. Internationale Beiträge zur Inneren Medizin 1, 597-610.

 

Stuehr, D.J. et Marletta, M.A. (1985) Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proceedings of the National Academy of Sciences USA 82, 7738-7742.

 

Sulotto, F., Romano, C., Insana, A., Carrubba Cacciola, M. et Cerutti, A. (1994) Valori normali di carbossiemoglobinemia e di metemoglobinemia in un campione di militari di leva. La Medicina del Lavoro 85, 289-298.

 

Sundqvist, T., Laurin, P., Fälth-Magnusson, K., Magnusson, K.-E. et Stenhammar, L. (1998) Significantly increased levels of nitric oxide products in urine of children with celiac disease. Journal of Pediatric Gastroenterology and Nutrition 27, 196-198.

 

Szaleczky, E. Pronai, L., Nakazawa, H. et Tulassay, Z. (2000) Evidence of in vivo peroxynitrite formation in patients with colorectal carcinoma, higher plasma nitrate/nitrite levels, and lower protection against oxygen free radicals. Journal of Clinical Gastroenterology 30, 47-51.

 

Takacs, S. (1987) Nitrate content of drinking water and tumours of the digestive organs. Zentralbatt fur Bakteriologie, Mikrobiologie und Hygiene B 184, 269-279.

 

Takacs, S., Kuncsik, K. Enyedi, T., Stecz, J. et Borsi, E. (1978) Study of methaemoglobinaemia in four countries. .Egeszsegtudomany 22, 239-244 (en hongrois).

 

Tanaka, S., Yashiro, A., Nakashima, Y., Nanri, H., Ikeda, M. et Kuroiwa, A. (1997) Plasma nitrite/nitrate level is inversely correlated with plasma low-density lipoprotein cholesterol level. Clinical Cardiology 20, 361-365.

 

Tankurt, E., Kirkali, G., Ozcan, M.A., Mersin, N., Ellidokuz, E. et Akpinar, H.A. (1998) Increased serum nitrite and nitrate concentration in chronic hepatitis. Journal of Hepatology 29, 512-513.

 

Tannenbaum, S.R. (1987) Endogenous formation of N-nitroso compounds: a current perspective. In: Bartsch, H., O'Neill, I.K. et Schulte-Hermann, R. (eds) Relevance of N-nitroso Compounds to Human Cancer: Exposures and Mechanisms. IARC Scientific Publications 84, Lyon, pp. 292-298.

 

Tanner, F.W. et Evans, F.L. (1933) Effect of meat curing solutions on anaerobic bacteria II. Sodium nitrate. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene 88, 48-54.

 

Tardieu, A. (1867) Etude Médiocolégale et Clinique sur l’Empoisonnement. J.B. Baillière et Fils, Paris.

 

Tarr, H.L.A. (1941) Bacteriostatic action of nitrates. Nature 147, 417-418.

 

Tarr, L. (1933) Transient methemoglobinemia due to ammonium nitrate. Archives of Internal Medicine 51, 38-44.

 

Tassin, M.S. et Michels, S. (1992) Trop de nitrates dans nos assiettes. Que Choisir 284, 25-29.

 

Thayer, J.R., Chasko, J.H., Swartz, L.A. et Parks, N.J. (1982) Gut reactions of radioactive nitrite after intratracheal administration in mice. Science 217, 151-153.

 

Thomsen, L.L., Baguley, B.C., Rustin, G.J.S. et O’Reilly, S.M. (1992) Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma II: induction of nitric oxide production. British Journal of Cancer 66, 723-727.

 

Thorens, J., Froelich, F., Schwizer, W., Saraga, E., Bille, J., Gyr, K., Duroux, P., Nicolet, M., Pignatelli, B., Blum, A.L., Gonvers, J.J. et Fried, M. (1996) Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Gut 39, 54-59.

 

Til, H.P., Falke, H.E., Kuper, C.F. et Willems, M.I. (1988) Evaluation of the oral toxicity of potassium nitrite in an 13-week drinking-water study in rats. Food and Chemical Toxicology 26, 851-859.

 

Tompkin, R.B. (1993) Nitrite. In: Davidson, P.M. et Branen, A.L. (eds) Antimicrobials in Foods, Marcel Dekker, 191-262.

 

Tricker, A.R. (1997) N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. European Journal of Cancer Prevention 6, 226-228.

 

Tricker, A.R., Pfundstein, B., Kälble, T. et Preussmann, R. (1992) Secondary amine precursors to nitrosamines in human saliva, gastric juice, blood, urine and faeces. Carcinogenesis 13, 563-568.

 

Tsezou, A., Kitsiou-Tzeli, S., Galla, A., Gourgiotis, D., Papageorgiou, J., Mitrou, S., Molybdas, P.A. et Sinaniotis, C. (1996) High nitrate content in drinking water: cytogenetic effects in exposed children. Archives of Environmental Health 51, 458-461.

 

Tsuji, S., Tsujii, M., Sun, W.-H., Gunawan, E.S., Murata, H., Kawano, S. et Hori, M. (1997) Helicobacter pylori and gastric carcinogenesis. Journal of Clinical Gastroenterology 25 (suppl 1): S186-S197.

 

Tsukahara, H., Miyanomae, T. et Sudo, M. (1997) Urinary nitrite/nitrate levels in children with bronchial asthma. European Journal of Pediatrics 156, 667.

 

Turek, B., Hlavsova, D., Tucek, J., Waldman, J. et Cerna, J. (1980) The fate of nitrates and nitrites in the organism.In: Walker, E.A. Griciute, L., Castegnaro, M. et Börzsönyi, M. (eds) N-nitroso Compounds; Analysis, Formation and Occurrence, IARC Scientific Publications 31, 625-632.

 

Uibu, J. Tauts, O., Levin, A., Shimanovskaya, N. et Matto, R. (1996) N-nitrosodimethylamine, nitrate and nitrate-reducing micro-organisms in human milk. Acta Paediatrica 85, 1140-1142.

 

Utiger, R.D. (1998a) A pill for impotence. New England Journal of Medicine 338, 1458-1459.

 

Utiger, R.D. (1998b) Effects of smoking on thyroid function. European Journal of Endocrinology 138, 368-368.

 

Vallance, P. et Collier, J. (1994) Biology and clinical relevance of nitric oxide. British Medical Journal 309, 453-457.

 

van Duijvenbooden, W. et Matthijsen, A.J.C.M. (eds) (1989) Integrated Criteria Document Nitrate Effects. Report no. 758473007, RIVM, Bilthoven, Netherlands (en hollandais ;  disponible en anglais : no. 758473012).

 

Van Leeuwen, J.A., Walter-Toews, D., Abernathy, T., Smit, B. et Shoukri, M. (1999) Associations between stomach cancer incidence and drinking water contamination with atrazine and nitrate in Ontario (Canada) agro-ecosystems, 1987-1991. International Journal of Epidemiology 28, 836-840.

 

Van Loon, A.J.M., Botterweck, A.A.M., Goldbohm, R.A., Brants, H.A.M., Van Klaveren, J.D. et Van Den Brandt, P.A. (1998) Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study. British Journal of Cancer 78, 129-135.

 

van Maanen, J.M.S., van Dijk, A., Mulder, K., de Baets, M.H., Menheere, P.C.A., van Der Heide, D., Mertens, P.L.J.M. et Kleinjans, J.C.S. (1994) Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid. Toxicology Letters 72, 365-374.

 

van Maanen, J.M., van Geel, A.A. et Kleinjans, J.C. (1996) Modulation of nitrate-nitrite conversion in the oral cavity. Cancer Detection and Prevention 20, 590-596.

 

van Maanen, J.M.S., Albering, H.J., van Breda, S.G.J., Curfs, D.M.J., Ambergen, A.W., Wolffenbutel, B.H.R., Kleinjans, J.C.S. et Reeser, H.M. (1999) Nitrate in drinking water and risk of childhood diabetes in the Netherlands. Diabetes Care 22, 1750.

 

van Maanen, J.M.S., Albering, H.J., de Kok, T.M.C.M., van Breda, S.G.J. Curfs, D.M.J., Vermeer, I.T.M., Amberger, A.W., Wolffenbuttel, B.H.R., Kleinjans, J.C.S. et Reeser, H.M. (2000) Does the risk of childhood diabetes mellitus require revision of the guideline values for nitrate in drinking water? Environmental Health Perspectives 108, 457-461.

 

Van Straaten, E.A., Koster-Kamphuis, L. Bovee-Oudenhoven, I.M., van der Meer, R. et Forget, P.P. (1999) Increased urinary nitric oxide oxidation products in children with active coeliac disease. Acta Paediatrica 88, 528-531.

 

Veisseyre, R. (1975) Technologie du Lait. Constitution, Récolte, Traitement et Transformation du Lait. La Maison Rustique, Paris, 714 pp.

 

Verdu, E., Viani, F., Armstrong, D., Fraser, R., Siegrist, H.H., Pignatelli, B., Idström, J-P., Cederberg, C., Blum, A.L. et Fried, M. (1994) Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Gut 35, 455-460.

 

Verger, P., Guillard, J.-M., Sandler, B. et Merlio, M. (1966) Méthémoglobinémies acquises du nourrisson par eau de canalisation urbaine. Journal de Médecine de Bordeaux 143, 1257-1261.

 

Vermeer, I.T.M., Pachen, D.M.F.A., Dallinga, J.W., Kleinjans, J.C.S. et van Maanen, J.M.S. (1998) Volatile N-nitrosamine formation after intake of nitrate at the ADI level in combination with an amine-rich diet. Environmental Health Perspectives 106, 459-465.

 

Viani, F., Siegrist, H.H., Pignatelli, B., Cederberg, C., Idström, J.-P., Verdu, E.F., Fried, M., Blum, A.L. et Armstrong, D. (2000) The effect of intra-gastric acidity and flora on the concentration of N-nitroso compounds in the stomach. European Journal of Gastroenterology and Hepatology 12, 165-173.

 

Vigil, J., Warburton, S., Haynes, W.S. et Kaiser, L.R. (1965) Nitrates in municipal water supply cause methemoglobinemia in infant. Public Health Reports 80, 1119-1121.

 

Viidas, U., Ahlmen, J., Hedner, T., Cajdahl, K., Larsson, A., Pettersson, A. et Strömbom U. (1998) Nitric oxide and blood pressure in normotensive patients on chronic hemodialysis. Dialysis and Transplantation 27, 714-724.

 

Ville, J. et Mestrezat, W. (1907) Origine des nitrites contenus dans la salive; leur formation par réduction microbienne des nitrates éliminés par ce liquide. Comptes Rendus des Séances de la Société de Biologie 63, 231-233.

 

Ville, J. et Mestrezat, W. (1908) Les nitrites salivaires; leur origine. Bulletin de la Société Chimique de France. Mémoires 3, 212-217.

 

Vincent, P., Dubois, G. et Leclerc, H. (1983) Nitrates dans l’eau de boisson et mortalité par cancer. Etude épidémiologique dans le nord de la France. Revue d’Epidémiologie et de Santé Publique 31, 199-207.

 

Virtanen, S.M. et Aro, A. (1994) Dietary factors in the aetiology of diabetes. Annals of Medicine 26, 469-478.

 

Virtanen, S.M., Jaakkola, L., Räsänen, L., Ylönen, K., Aro, A., Lounamaa, R., Akerblom, H.K., Tuomilehto, J. et the Childhood Diabetes in Finland Study Group (1994) Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Diabetic Medicine 11, 656-662.

 

Vleeming, W., van de Kuil, A., te Biesebeek, J.D., Meulenbelt, J. et Boink, A.B. (1997) Effect of nitrite on blood pressure in anaesthetized and free-moving rats. Food and Chemical Toxicology 35, 615-619.

 

von Bodo, T. (1955) Uber “Alimentäre” Nitrat-Methämoglobinämien im Frühen Säuglingsalter. Monatsschrift für Kinderheilkunde 103, 8-11.

 

Wagner, D.A., Schultz, D.S., Deen, W.M., Young, V.R. et Tannenbaum, S.R. (1983a) Metabolic fate of an oral dose of 15N–labeled nitrate in humans: effect of diet supplementation with ascorbic acid. Cancer Research 43, 1921-1925.

 

Wagner, D.A., Young, V.R. et Tannenbaum, S.R. (1983b) Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment. Proceedings of the National Academy of Sciences USA 80, 4518-4521.

 

Walker, R. (1990) Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications. Food Additives and Contaminants 7, 717-768.

 

Walker, R. (1995) The conversion of nitrate into nitrite in several animal species and man. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite). Bilthoven (Netherlands), 8-10 November 1994. Council of Europe Press, Strasbourg, pp. 115-123.

 

Walker, R. (1996) The metabolism of dietary nitrites and nitrates. Biochemical Society Transactions 24, 780-785.

 

Wallace, J.L., Elliot, S.N., Del Soldato, P. McKnight, W., Sannicolo, F. et Cirino, G. (1997) Gastrointestinal-sparing anti-inflammatory drugs: the development of nitric oxide-releasing NSAIDs. Drug Development Research 42, 144-149.

 

Walton, G. (1951) Survey of literature relating to infant methemoglobinemia due to nitrate-contaminated water. American Journal of Public Health 41, 986-996.

 

Walton, K., Walker, R., van de Sandt, J.J.M., Castell, J.V., Knapp, A.G.A.A., Kozianowski, G., Roberfroid, M. et Schilter, B. (1999) The application of in vitro data in the derivation of the acceptable daily intake of food additives. Food and Chemical Toxicology 37, 1175-1197.

 

Wang , C.F., Cassens, R.G. et Hoekstra, W.G. (1981) Fate of ingested 15N-labelled nitrate and nitrite in the rat. Journal of Food Science 46, 745-748.

 

Ward, M.H., Mark, S.D., Cantor, K.P., Weisenburger, D.D., Correa-Villasenor, A. et Zahm, S.H. (1996) Drinking water nitrate and the risk of non-Hodgkin’s lymphoma. Epidemiology 7, 465-471.

 

Weller, R., Pattullo, S., Smith, L., Golden, M., Ormerod, A. et Benjamin, N. (1996) Nitric oxide is generated on the skin surface by reduction of sweat nitrate. Journal of Investigative Dermatology 107, 327-331.

 

Weller, R., Price, R., Ormerod, A., Benjamin, N. et Leifert, C. (1997) Antimicrobial effect of acidified nitrite on skin commensals and pathogens. British Journal of Dermatology 136, 464.

 

Weller, R., Ormerod, A.D., Hobson, R.P. et Benjamin, N.J. (1998) A randomised trial of acidified nitrite cream in the treatment of tinea pedis. Journal of the American Academy of Dermatology 38, 559-563.

 

Wendel, W.B. (1939) The control of methemoglobinemia with methylene blue. Journal of Clinical Investigation 18, 179-185.

 

Wennmalm, A., Benthin, G. et Peterrson, A.-S. (1992) Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin. British Journal of Pharmacology 106, 507-508.

 

Wennmalm, A., Benthin, G., Edlung, A., Jungersten, L., Kieler-Jensen, N., Lundin, S., Westfelt, U.N., Petersson, A.-S. et Waagstein, F. (1993) Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circulation Research 73, 1121-1127.

 

Wettig, K., Schulz, K.-R., Scheibe, J., Broschinski, L., Diener, W., Fischer, G. et Namaschk, A. (1989) Nitrat- und Nitritgehalt in Speichel, Urin, Blut und Liquor von Patienten einer Infectionsklinik. Wiener Klinische Wochenschrift 101, 386-388.

 

Wettig, K., Dobberkau, H.J. et Flentje, F. (1990) Elevated endogenous nitrate synthesis associated with giardiasis. Journal of Hygiene, Epidemiology, Microbiology and Immunology 34, 69-72.

 

Wheeler, P. et Björnsäter, B.R. (1992) Seasonal fluctuations in tissue nitrogen, phosphorus, and N: P for five macroalgal species common to the Pacific Northwest coast. Journal of Phycology 28, 1-6.

 

WHO. (1962) Evaluation of the Toxicity of a Number of Antimicrobials and Antioxidants. Sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series 228. WHO, Geneva, pp. 69-72.

 

WHO (1970) European Standards for Drinking Water. 2nd edn. WHO, Geneva.

 

WHO (1971) International Standards for Drinking Water. 3rd edn. WHO, Geneva.

 

WHO (1974) Toxicological Evaluation of Some Food Additives Including Anticaking Agents, Antimicrobials, Antioxidants, Emulsifiers and Thickening Agents. Prepared by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Food Additives Series 5. WHO, Geneva, pp. 92-109.

 

WHO (1978) Nitrates, Nitrites and N-nitroso Compounds. Environmental Health Criteria 5. WHO, Geneva.

 

WHO (1984) Guidelines for Drinking Water Quality. Vol. 2. Health Criteria and Other Supporting Information. WHO, Geneva, pp. 128-134.

 

WHO (1985) Health Hazards from Nitrates in Drinking-water. Report on a WHO meeting 5-9 March 1984. WHO, Copenhagen.

 

WHO (1993a) Guidelines for Drinking-water Quality. 2nd edn. Vol. 1. Recommendations. WHO, Geneva. pp 52-53.

 

WHO (1993b) Guidelines for Drinking-water Quality. 2nd edn. Vol. 2, Health Criteria and Other Supporting Information. WHO, Geneva. pp 313-324.

 

WHO (1995) Evaluation of Certain Food Additives and Contaminants. Forty-fourth report of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series 859. WHO, Geneva, pp. 29-35.

 

WHO (1996) Toxicological Evaluation of Certain Food Additives and Contaminants in Food. Prepared by the 44th meeting on the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Food Additives Series 35. WHO, Geneva, pp. 269-360.

 

WHO, (2001) Water Resources and Human Health in Europe. WHO, Regional Office for Europe, Copenhagen (in press).

 

Wigand, R., Meyer, J., Busse, R. et Hecker, M. (1997) Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of increased nitric oxide synthase activity. Annals of the Rheumatic Diseases 56, 330-332.

 

Williams, D.L.H. (1988) Nitrosation. Cambridge University Press. Cambridge, U.K.

 

Willis, T. (1674) Pharmaceutics Rationalis, London, p74.

 

Wilson, W.S., Ball, A.S. et Hinton, R.H. (eds) (1999) Managing Risks of Nitrates to Humans and the Environment. The Royal Society of Chemistry, Cambridge, UK, 339 pp.

 

Wink, D.A., Vodovotz, Y., Laval, J., Laval, F., Dewhirst, M.W. et Mitchell, J.B. (1998) The multifaceted roles of nitric oxide in cancer. Carcinogenesis 19, 711-721.

 

Winkler, S., Menyawi, I.E., Linnau, K.F. et Graninger, W. (1998) Short report: Total serum levels of the nitric oxide derivatives nitrite/nitrate during microfilarial clearance in human filarial disease. American Journal of Tropical Medicine and Hygiene 59, 523-525.

 

Winlaw, D.S., Smythe, G.A., Keogh, A.M., Schyvens, C.G., Spratt, P.M. et Macdonald, P.S. (1994) Increased nitric oxide production in heart failure. Lancet 344, 373-374.

 

Winton, E.F., Tardiff, R.G. et McCabe, L.J. (1971) Nitrate in drinking water. Journal of the American Water Works Association 63, 95-98.

 

Wirth, S. et Vogel, K. (1998) Cow's milk protein intolerance in infants with methaemoglobinaemia and diarrhoea. European Journal of Pediatrics 148, 172.

 

Witter, J.P. et Balish, E. (1979) Distribution and metabolism of ingested NO3- and NO2- in germfree and conventional-flora rats. Applied and Environmental Microbiology 38, 861-869.

 

Witter, J.P., Gatley, S.J. et Balish, E. (1979) Distribution of Nitrogen-13 from labelled nitrate (13NO3-) in humans and rats. Science 204, 411-413.

 

Wolff, I.A. et Wasserman, A.E. (1972) Nitrates, nitrites and nitrosamines. Extensive research is needed to establish how great a food hazard these nitrogenous substances present. Science 177, 15-19.

 

Wong, H.R., Carcillo, J.A., Burckart, G. et Kaplan, S.S. (1996) Nitric oxide production in critically ill patients. Archives of Disease in Childhood 74, 482-489.

 

Wyngaarden, J.B., Wright, B.M. et Ways, P. (1952) The effect of certain anions upon the accumulation and retention of iodide by the thyroid gland. Endocrinology (Philadelphia) 50, 537-549.

 

Yamada, Y., Endo, S., Kamei, Y., Minato, T., Yokoyama, M., Taniguchi, S., Nakae, H., Inada, K. et Ogawa, M. (1998) Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns. Burns 24, 513-517.

 

Yang, C.S. (1980) Research on esophageal cancer in China: a review. Cancer Research 40, 2633-2644.

 

Yang, C.-Y., Cheng, M.-F., Tsai, S.-S. et Hsieh, Y.-L. (1998) Calcium, magnesium and nitrate in drinking water and gastric cancer mortality. Japanese Journal of Cancer Research 89, 124-130.

 

Yang, D., Lang, U., Greenberg, S.G., Myatt, L. et Clark, K.E. (1996) Elevation of nitrate levels in pregnant ewes and their fetuses. American Journal of Obstetrics and Gynecology 174, 573-577.

 

Zaldivar, R. et Wetterstrand, W.H. (1978) Nitrate nitrogen levels in drinking water of urban areas with high- and low- risk populations for stomach cancer: an environmental epidemiology study. Zeitschrift für Krebsforschung und Klinische Onkologie 92, 227-234.

 

Zandjani, F., Hogsaet, B., Andersen, A. et Langard, S. (1994) Incidence of cancer among nitrate fertilizer workers. International Archives of Occupational and Environmental Health 66, 189-193.

 

Zangerle, R., Fuchs, D., Reibnegger, G., Werner-Felmayer, G., Gallati, H., Wachter, H. et Werner, E.R. (1995) Serum nitrite plus nitrate in infection with human immunodeficiency virus type–1. Immunobiology 193, 59-70.

 

Zeballos, G.A., Bernstein, R.D., Thompson, C.I., Forfia, P.R., Seyedi, N., Shen, W., Kaminski, P.M., Wolin, M.S. et Hintze, T.H. (1995) Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 91, 2982-2988.

 

Zeilmaker, M.J. et Slob, W. (1995) Physiologically based toxicokinetic modelling of nitrate and nitrite: implications for the safety evaluation of nitrate. In: Proceedings of the International Workshop on Health Aspects of Nitrates and its Metabolites (Particularly Nitrite), Bilthoven (Netherlands), 8-10 November 1994, Council of Europe Press, Strasbourg, pp. 299-312.

 

Zhu, L., Gunn, C. et Beckman, J.S. (1992) Bactericidal activity of peroxynitrite. Archives of Biochemistry and Biophysics 298, 452-457.

 

Zmirou, D., Lefevre, F. et Cote, R. (1993) Incidence de la méthémoglobinémie du nourrisson en France: données récentes. In: Colloque: “Les nitrates”. Effet de Mode ou Vrai Problème de Santé? Ecole Nationale de la Santé Publique. Rennes. pp 1-11.

 

Zmirou, D., Lefevre, F. et Cote, R. (1994) Incidence de la méthémoglobinémie du nourrisson en France: données récentes. In: Les Nitrates. Effet de Mode ou Vrai Problème de Santé?  Collection Santé et Société. Société Française de Santé Publique no. 1, pp. 102-113.

   


 

 

 

 

 

Faut-il encore avoir peur des nitrates ?

Christian BUSON

De nos jours, les nitrates font l'objet d'un consensus général. La réglementation sur l'eau potable, les programmes de " reconquête " de la qualité des eaux, les investissements prévus sur les ouvrages d'épuration, les mises aux normes des exploitations agricoles, tout est essentiellement conduit en vue d'un objectif suprême et apparemment incontesté : la baisse des taux de nitrates dans les milieux et, en particulier, dans l'eau. Il paraît utile, alors que des sommes considérables doivent encore être investies dans ce but, d'examiner, à la lumière des connaissances actuelles, le rôle exact de cet anion vis-à-vis de notre santé et de notre environnement, puis de tenter une synthèse à propos des nitrates.

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